Science and Technology Center on Real-Time Functional Imaging (STROBE)

了解物质在纳米和原子尺度上的结构和演化对于科学技术的发现和创新、加速材料科学、凝聚态物理、化学、生物学、工程学、地质学和医学的进步至关重要。这个科学和技术中心(STC)旨在利用电子、X射线、光学和纳米探针显微镜来推进和整合不同的成像方式，以共同应对重大科学挑战。它汇集了来自科罗拉多大学博尔德分校、加州大学伯克利分校、洛杉矶分校和欧文分校、佛罗里达国际大学和刘易斯堡学院的跨学科团队，与国家实验室、美国行业和国际合作者合作。教育和多样性：该STC开发、实施、评估和传播新的项目，以培养不同群体的学生在成像科学和技术方面具有创新能力和全球竞争力。它特别关注两个标志性的努力：(I)新的多学科研究生证书和学位计划，以及(Ii)多年、跨机构的本科生、硕士和博士学位计划。该中心的教育活动旨在实现以下版本的未来：K-12学生将抓住科学和工程职业的令人兴奋的机会。本科生将理解科学和工程的不同领域之间的联系，以及这些领域和工业之间的关系。博士毕业生将通过创业获得具有深度和广度的专业知识，以创新、领导团队研究和创造新技术。知识转移：该STC旨在通过在尖端成像科学方面的国内和国际领先地位、受过多学科科学培训的急需的多样化毕业生以及大量混合/自适应成像模式和桌面系统来展示，使新的科学能够在未来几十年涌现，并向行业和新兴初创公司转移技术。更快、更高分辨率和更灵敏的成像技术将造福于广泛的科学学科以及各个工业部门，这可以直接将技术进步转化为改善经济和生活水平。研究中心的技术说明：该STC的主要目标是解决所有成像模式共同的关键交叉挑战，并解决跨不同学科的科学重大挑战。当高速直接探测器、先进算法、大数据处理方法、新的光和电子源(包括桌面相干X射线源)以及光谱/空间/时间结构照明的进步被集成在一起时，它们可以从根本上改变成像科学，使实时三维功能成像成为可能。此外，通过将电子成像与光学成像相结合，或相干X射线成像与超快激光相结合，或相干红外光谱与纳米探针成像相结合，该中心的科学家们研究了远远超过当前能力的新的混合和自适应成像方式。一个预期的结果是创建和集成一套新的强大和广泛应用的实时成像模式，这些模式可以成像非晶体系统，并实现大视场、化学和磁对比度以及原子/分子/纳米级分辨率的动态成像。每种成像技术都将达到其基本极限，并集成到混合/自适应模式中，超过各部分的总和。

Understanding the structure and evolution of matter at the nanometer and atomic scales is central for discovery and innovation in science and technology, accelerating advances in materials science, condensed matter physics, chemistry, biology, engineering, geology, and medicine. This Science and Technology Center (STC) aims to advance and integrate different imaging modalities using electron, X-ray, optical, and nano-probe microscopy to collectively tackle major scientific challenges. It brings together an interdisciplinary team from University of Colorado at Boulder; Universities of California at Berkeley, Los Angeles, and Irvine; Florida International University; and Fort Lewis College, in partnership with national laboratories, US industries, and international collaborators.Education and Diversity: This STC develops, implements, assesses, and disseminates new programs to educate a diverse group of students to be innovative and globally competitive in imaging science and technology. It focuses particularly on two signature efforts: (i) new multidisciplinary graduate certificate and degree programs and (ii) multi-year, cross-institutional undergraduate, master's, and Ph.D. degree programs. The center's education activities are designed to realize the following version of the future: K-12 students will apprehend the exciting opportunities of science and engineering careers. Undergraduate students will appreciate the connections between different areas of science and engineering, as well as the relation between these fields and industry. Ph.D. graduates will acquire expertise with depth and breadth to innovate, lead team research, and create new technologies through entrepreneurship.Knowledge Transfer: This STC aims to manifest through national and international leadership in cutting-edge imaging science, highly-needed diverse graduates trained in multidisciplinary science, and a plethora of hybrid/adaptive imaging modalities and tabletop systems, enabling new science to emerge in the upcoming decades, as well as technology transfer to industry and emerging startups. Faster, higher-resolution and more sensitive imaging techniques will benefit a wide range of scientific disciplines as well as various industrial sectors, which can directly translate technological advances to improving the economy and the standard of living.Technical Description of the Center Research:A major goal of this STC is to address key cross-cutting challenges common to all imaging modalities and tackle science grand challenges across different disciplines. When advances in high-speed direct detectors, advanced algorithms, big-data manipulation methods, new light and electron sources (including tabletop coherent X-ray sources), and spectrally/spatially/temporally structured illumination are integrated, they can fundamentally transform imaging science to enable real-time three-dimensional functional imaging. In addition, by combining electron with optical imaging, or coherent X-ray imaging with ultrafast lasers, or coherent infrared spectroscopies with nano-probe imaging, scientists in this center investigate new hybrid and adaptive imaging modalities that far exceed current capabilities. An expected outcome is creation and integration of a new set of powerful and broadly applicable real-time imaging modalities that can image non-crystalline systems and implement dynamic imaging with a large field of view with chemical and magnetic contrast and with atomic/molecular/nanoscale resolution. Each imaging technique will be brought to reach its fundamental limits and integrated in hybrid/adaptive modalities that surpass the sum of the parts.