New catalytic chemistry based on borylation of alkynes

化学系的化学催化计划支持德克萨斯州A M大学化学系的教员Oleg Ozerov教授的项目。 Ozerov小组的工作横跨有机化学和无机化学领域。他的团队正在探索最近发现的将碳-硼键引入有机化合物的催化过程，特别是围绕碳-碳三键（炔）和双键（烯烃）。 这些硼化化合物的重要性在于它们作为更复杂有机分子的构建单元的多功能性，在药物和新材料的合成中具有潜在的应用。 该项目受益于美国和国际合作者的网络，包括主要本科院校（PUI）的合作者。 它也作为一种工具，扩大参与得克萨斯州A M研究生课程和教育得克萨斯州A M研究生关于PUI的职业生涯，并介绍他们到中学outreach. This项目的主要目标是探索的全部潜力的末端炔（DHBTA）和反应衍生it. Successfully实施硼化过程的利益需要开发的分子过渡金属催化剂的框架内专门设计的支持配体。 该项目旨在深入了解铱催化的DHBTA和其他硼基化反应的机理以及支持配体在影响反应结果中的作用。 正在研究的其他目标包括1）DHBTA产物、炔基硼酸酯的环化反应，和2）DHBTA激发的反应性在催化其他C-H硼基化反应中的潜力。 本科生直接参与Ozerov小组，并与Ithaca学院的Larsen教授和其他PUI教师合作。 PUI合作介绍得克萨斯州A M研究生PUI的机会和职业，并吸引更多的本科生进入研究和研究生教育。

The Chemical Catalysis Program of the Chemistry Division supports the project by Professor Oleg Ozerov, a faculty member in the Department of Chemistry at Texas A&M University. The work in the Ozerov group straddles the fields of organic and inorganic chemistry. His group is exploring recently discovered catalytic processes to introduce carbon-boron bonds into organic compounds, especially around carbon-carbon triple bonds (alkynes) and double bonds (alkenes). The importance of these borylated compounds is in their versatility as building blocks for more complex organic molecules, with potential applications in the synthesis of pharmaceuticals and new materials. The project benefits from a network of US and international collaborators, including those at primarily undergraduate institutions (PUI). It also serves as a vehicle for broadening participation in the Texas A&M graduate program and educating Texas A&M graduate students about PUI careers and introducing them to secondary school outreach.The primary goal of this project is the exploration of the full potential of dehydrogenative borylation of terminal alkynes (DHBTA) and the reactions derived from it. Successful implementation of the borylation processes of interest requires development of molecular transition metal catalysts in a framework of specifically designed supporting ligands. The project aims to gain fundamental insight into the mechanism of iridium-catalyzed DHBTA and other borylation reactions and the role of the supporting ligand in influencing reaction outcomes. Other goals being investigated include 1) the cyclization reactions of DHBTA products, alkynylboronates, and 2) the potential of the DHBTA-inspired reactivity in catalysis of other C-H borylation reactions. Undergraduate students are involved directly in the Ozerov group and via collaboration with Prof. Larsen at Ithaca College and other PUI faculty. PUI collaborations introduce Texas A&M graduate students to PUI opportunities and careers and draw more undergraduates into research and into graduate education.