First Principles Design of Second-Generation Protein Stains

蛋白质组学是一门新兴的技术，它有可能给现代生物学和医学带来革命性的变化。极其敏感的蛋白质染色是一项关键的蛋白质组学技术，与凝胶电泳相结合，它们有助于快速、定量地检测细胞中的所有多肽。然而，蛋白质组学的工具必须迅速发展(更便宜、更灵敏、更可靠、操作更安全)，才能使技术成熟到充分发挥其潜力的阶段。我们将通过设计第二代荧光蛋白染色来实现蛋白质组学的进化，使用环保的天然产品表康酮作为我们的设计平台。

Proteomics is an emerging technology which has the potential to revolutionize modern biology and medicine. Extremely sensitive protein stains are a key proteomics technology, and in conjunction with gel electrophoresis, they facilitate the rapid and quantitative detection of all polypeptides in a cell. However, the tools of proteomics must rapidly advance (cheaper, greater sensitivity, more reliable, safer to handle) before the technology can mature to the stage where its full potential is realized. We will enable the evolution of proteomics by devising second generation fluorescent protein stains, using the environmentally-friendly natural product, epicocconone, as our design platform.