Asymmetric ion-pair catalysis

近年来，无金属、低分子量分子已成为一种强有力的催化剂，并成功地应用于各种高对映选择性的转化反应。在迄今报道的不同催化领域中，离子对催化领域直到最近才发展成为一个重要的研究领域，各种涉及亚胺和羰基活化的不对称反应已经实现。尽管已经取得了重大进展，但由强酸性催化剂催化的不对称反应的例子仍然很少。在这种背景下，我们计划合成新的手性强酸催化剂，以实现到目前为止尚未实现的高价值的不对称化学转化。将特别关注手性离子对催化的概念，较少碱性底物的活化，以及传统上在金属催化下进行的实用和高效的对映选择性转化的发展。

In recent years metal free, low molecular weight molecules have emerged as powerful catalysts and have successfully been applied in various highly enantioselective transformations. Among the different areas of catalysis reported to date, the domain of ion-pair catalysis has only recently evolved as an important field of research and a variety of asymmetric reactions involving imine and carbonyl activations have been realized. Despite the significant advances made, examples of asymmetric reactions catalyzed by strongly acidic catalysts are still rare. In this context, we plan to synthesize new chiral strongly acidic catalysts for the realization of highly valuable asymmetric chemical transformations, which have not been achieved to date. A special focus will be directed to the concept of chiral ion-pair catalysis, the activation of less basic substrates and the development of practical and efficient, enantioselective transformations which are traditionally performed under metal catalysis.