Vascular Tissue Road-mapping Workshop & Micro-gravity Impact Roundtable

2016年8月20日，NeubertNSF在加州山景城NASA艾姆斯研究中心举行了“血管组织道路测绘研讨会和微重力影响圆桌会议”，为参与者的差旅费用和管理费用提供了支持。该提案以2015年NSF BME资助的研讨会为基础，该研讨会制定了路线图，确定了结束器官短缺的途径、里程碑和挑战。本次研讨会的重点是确定的里程碑之一，“厚组织血管化”，这导致美国宇航局启动了“血管组织挑战”，并提供了50万美元的奖金给第一个研究小组，他们可以成功地使1厘米厚的组织血管化，其中有活跃的实质细胞（肝，肺，心脏，肌肉，肾细胞）。虽然对可能的技术了解很多，但对微重力可能带来的好处知之甚少。研讨会将为追求血管化目标的研究界提供一个机会，以更好地了解这条道路上的里程碑，并了解更多可能的实现机会。研讨会将分为三个部分：1)血管组织路线图会议，2)血管组织挑战团队峰会，以及3)微重力环境对组织工程影响的圆桌会议。预期产出包括：1)关于解决器官短缺的血管化途径的路线图报告，其中将包括确定和描述研究和资助团体共同感兴趣的具体里程碑和挑战；2)厚组织血管化技术现状白皮书；3)关于厚组织血管形成研究小组可用资源和机会的白皮书；4)关于微重力对厚组织血管形成影响的知识现状的白皮书。主讲人和参与者将通过血管组织挑战团队名单，现有的新器官咨询委员会成员和厚组织血管化研究界进行策划。该研讨会有望在结束器官短缺的生物工程途径上利用新的关系来获得额外的奖项和挑战。最终，这种崇拜将有助于实现为有需要的患者提供再生的、工程化的器官和组织的目标。

1642055 - NeubertNSF has made an award in support of participant travel costs and management costs associated with the "Vascular Tissue Road-mapping Workshops & Micro-gravity Impact Roundtable" being held in the Mountain View, CA, at the NASA Ames Research Center, August 20, 2016. The proposal builds upon a previous 2015 NSF BME funded workshop in which a Roadmap was created identifying pathways, milestones, and challenges toward ending the organ shortage. This workshop focuses on one of the identified milestones, "thick-tissue vascularization," which has led to NASA's launch of a "Vascular Tissue Challenge" with a $500,000 prize purse provided to the first research groups that can successfully vascularize 1 cm thick tissues with active parenchymal cells (liver, lung, heart, muscle, kidney cells.) Though much is known about possible techniques, very little is known about the possible enabling benefits of microgravity. The workshop will provide the research community pursuing this vascularization goal an opportunity to better understand the milestones along this pathway and learn more about possible enabling opportunities.The workshop will be conducted in 3 parts: 1) a Vascular Tissue Road-mapping session, 2) a Vascular Tissue Challenge Team Summit, and 3) a Roundtable on the micro-gravity environment's impact on tissue engineering. Outputs expected include: 1) A Road-mapping Report on the Vascularization Pathway towards solutions to the organ shortage that will include identification and descriptions of specific milestones and challenges along this pathway of mutual interest to the research and funding communities; 2) A White Paper on the current state of the art in thick-tissue vascularization; 3) A White Paper on available resources and opportunities for research groups pursuing thick-tissue vascularization and 4) A White Paper on the current state of knowledge about the impacts of micro-gravity on thick-tissue vascularization. Keynote speakers and participants will be curated through the Vascular Tissue Challenge team roster, existing New Organ Advisory Board members and the thick-tissue vascularization research community. The workshop is expected to leverage new relationships for additional prizes and challenges on the bioengineering pathways toward ending the organ shortage. Ultimately, the worship will help advance the goal of making regenerated, engineered organs and tissues available to patients who need them.