Building a TERM Roadmap for Organ Disease, Washington, DC, March 16-17, 2015

PI：Neubert，Josh计划编号：1521828在过去的十年中，研究小组在干细胞科学、组织和生物医学工程、冷冻保存和其他再生医学领域取得了巨大进展，这些领域已经开始显示出令人振奋的结果。然而，为器官疾病和损伤，特别是心脏、肝脏、肺和肾脏等复杂器官提供临床适用的解决方案的能力，对大多数研究人员来说是难以实现的。对器官损伤解决方案的需求从未像现在这样强烈。在过去20年里，等待捐赠器官的人数迅速增加，而捐赠者的数量却停滞不前。据估计，35%的美国人的死亡可以通过器官修复或移植来预防或显著推迟。需要新的解决方案来满足这一需求。研究人员提出了一项景观分析研究和研讨会，以确定创建这些解决方案的关键里程碑。这项工作将创建一个关键路径路线图，以解决器官损伤问题。这一路线图将包括纳入技术进步创新方法的具体机会，例如可用于补充、增强和利用传统研究资助的奖励和奖励。研讨会将于2015年3月16日至17日在华盛顿特区举行，届时将召集学术界、工业界和政府机构的主要利益相关者。研究人员为这次研讨会确定了三个主要成果：(1)确定将在解决器官疾病的道路上开启关键机会的关键量化里程碑；(2)确定如何最好地确定何时拟议的研究途径或里程碑将无法实现，以帮助将未来的研究计划集中于潜在的成功结果；以及(3)确定机会，以推进量化里程碑，并利用激励创新模式(奖励、挑战、奖励等)补充或更好地针对现有研究资助计划。研讨会期间确定了四个潜在里程碑的主题领域供讨论：法规、组织与生物医学工程、冷冻保存和制造/临床支持。在讲习班之前，将与主要利益攸关方进行面谈，以收集初步信息，确定这四次会议的每一次科学讨论的内容。研讨会结束后，将向公众介绍和传播关于推进器官疾病解决方案的路线图、里程碑和新方法的具体指导方针、里程碑和标准。

PI: Neubert, Josh Proposal Number: 1521828In the last decade, research groups have made great advances in stem cell science, tissue and biomedical engineering, cryopreservation, and other areas of regenerative medicine that have begun to show promising results. However, the ability to produce clinically applicable solutions to organ disease and impairment, especially in complex organs such as the heart, liver, lungs, and kidneys, has for the most-part eluded researchers. The need for solutions to organ impairment has never been greater. The organ waitlist has grown rapidly over the last two decades while the number of donors has stagnated. It is estimated that 35% of all U.S. deaths could be prevented or significantly delayed by organ repair or transplantation. New solutions are required to meet this demand. The investigators propose a landscape analysis study and workshop to identify key milestones toward creating these solutions. The work will create a critical-path roadmap toward solutions to organ impairment. Included in this roadmap will be specific opportunities to incorporate innovative methods for technology advancement such as prizes and awards that can be used to supplement, enhance, and leverage traditional research grants. The workshop will be hosted in Washington DC on March 16-17, 2015, convening key stakeholders from academia, industry, and government agencies. The investigators have defined three primary outcomes for this workshop: (1) Identify key quantitative milestones that will open critical opportunities on the road to solving organ disease; (2) Determine how to best identify when a proposed research avenue or milestone will not be achieved to help focus future research initiatives on potentially successful outcomes; and (3) Identify opportunities to advance quantitative milestones and supplement or better target existing research grant programs using incentivized innovation models (prizes, challenges, awards, etc.). Four topic areas of potential milestones have been identified for discussion during the workshop: Regulation, Tissue & Biomedical Engineering, Cryopreservation, and Manufacturing/Clinical support. Prior to the workshop, key stakeholder interviews will be conducted to gather preliminary information defining the content of the scientific discussions for each of these four sessions. Upon conclusion of the workshop, specific guidelines, milestones, and criteria will be presented and disseminated to the public concerning the roadmap, milestones, and new methodologies for advancing solutions to organ disease.