Research Coordination Network (RCN): Predicting vertebrate responses to a changing climate: modeling genomes to phenomes to populations (G2P2PoP)

生物学中的一个重大挑战是理解基因、环境和表型之间的机械相互关系，以及这些相互作用如何在种群水平上出现。该项目涉及建立一个研究协调网络，将数学建模和生物学领域的科学家聚集在一起，开发多层次机制模型，将现有数据和新数据结合在一起，以预测脊椎动物对环境变化相关应激源的反应。具体目标包括建立一个具有不同生物复杂性水平和/或创建和使用数学模型专长的参与者的初始核心网络，扩大原有网络，特别侧重于招聘青年科学家，举办讲习班以促进教育和形成新的跨学科合作，通过实验室之间的交流进行培训，以及开发和传播讲习班产生的网络研讨会。参与者的科学、区域、性别和种族多样性将扩大参与者的参与，并使参与者接触到不同的社会和科学文化。在最初的参与者中，有8个国家的代表，大约一半是职业生涯早期的人，超过一半是女性，许多人是科学界代表性不足的群体的成员。通过综合经验科学和建模，可以产生新的知识，并将其用于向关键利益攸关方提供信息，包括政策制定者、土地管理人员和普通公众。该项目将招聘中学教师，通过教师外展，培训和开发课程模块，将其纳入高中科学计划，开发公共教育资源的网络研讨会，并创建供研究人员使用的网络研讨会。这个研究协调网络将应对生物学中的一个重大挑战，将扩展到人口层面，即破译基因组与表观组(G2P)的关系。这种理解对于预测动物对快速环境变化的恢复力和脆弱性至关重要。参与者的专业知识将从基因组到种群，并将包括各级生物组织的定量建模人员。主要活动包括年度研讨会，以促进数学建模人员和有机体科学家之间的讨论和互动。*每个研讨会将包括在一个主题领域内由专家进行互动讲座，然后讨论建模方法以及生物组织内部和跨级别的限制和机会。下一步将是交流产生生物数据和建模的新技术和方法，然后是为新的合作和筹资机会规划会议。将组织网络研讨会，对参与者进行各级生物系统的机械建模方面的培训。将通过对网络参与者的跨学科交流进行投资，促进在研究和生成手稿和提案方面的合作。将建立一个网站和一个讨论委员会，供成员之间进行深入讨论和合作。该网站将作为参与者专门知识和活动的描述以及每个讲习班的报告的储存库，并由专家发言者进行视频演示。

A grand challenge in biology is developing an understanding of the mechanistic interrelationships among genes, environment, and phenotype, and how these interactions emerge at the population level. This project involves establishing a research coordination network, to bring together scientists from mathematical modeling and biological fields to develop multilevel mechanistic models that integrate existing and new data to predict responses by vertebrates to environmental change-related stressors. Specific goals include the creation of an initial core network of participants with expertise either at different levels of biological complexity and/or at creating and using mathematical models, expansion of the original network with special emphasis in recruiting young scientists, hosting workshops to foster education and formation of new interdisciplinary collaborations, training through exchanges between labs, and development and dissemination of webinars derived from the workshops. Scientific, regional, gender and ethnic diversity of the participants will broaden participation and expose participants to diverse social and scientific cultures. Of the initial participants, eight nations are represented, about half are early career, over half are female, and many are members of under-represented groups in science. Through the synthesis of empirical science and modeling, new knowledge can be generated and used to inform key stakeholders including policymakers, land managers, and the general public. The project will recruit secondary school teachers for training and development of curricular modules for incorporation into high school science programs through teacher outreach, develop webinars for public education resources, and create webinars for use by researchers.This research coordination network will address a grand challenge in biology, 'Deciphering the Genomes-to-Phenomes (G2P) Relationship' with extension to the population level. This understanding is essential for predicting animal resilience and vulnerability to rapid environmental change.  Participant expertise will span from genomes to populations and will include quantitative modelers at all levels of biological organization. Primary activities include annual workshops to foster discussion and interaction among mathematical modelers and organismal scientists.  Each workshop will include interactive lectures by experts within a topic area, followed by discussion of modeling approaches, and limitations and opportunities within and across levels of biological organization. Next will be communication of new techniques and approaches to generation of biological data and modeling, followed by planning sessions for new collaborations and funding opportunities.  Webinars will be organized to train participants in mechanistic modeling of biological systems across levels.  Collaborations in research and generation of manuscripts and proposals will be facilitated through investment in cross-disciplinary exchanges of network participants. A website will be established with a discussion board for in-depth discourse and collaboration among members. The website will serve as a repository for descriptions of participant expertise and activities, as well as reports of each workshop, with video presentations by the expert speakers.