Chemoenzymatic Total Synthesis of Ambruticins and Jerangolids

该项目旨在使聚酮生物合成的后期生物合成酶(裁剪酶)适用于化学天然产物合成的生物催化工具。根据它们的天然作用，它们将被用来替代全合成的后期和关键步骤。因此，合成部分的目标结构更简单，衍生物更容易获得。所选方法的有效性将在鹅膏菌素和牛膝内酯上得到验证。将化学合成和生物合成相结合的化学酶全合成将被开发出来，并用于合成新的衍生物。

This project aims to make late-stage biosynthetic enzymes (tailoring enzymes) from polyketide biosynthesis applicable as biocatalytictools for chemical natural product synthesis. According to their natural role, they will be used to substitute lateand crucialstepsin the endgameof total syntheses. Thereby, thetarget structures for the synthetic part are simpler and derivatives become easier accessible. The usefulness of the chosen approach will be demonstrated onthe ambruticins and the jerangolids.Chemoenzymatic total synthesesthat merge chemical synthesis with biosynthesis will be developedand be used to accessnovel derivatives.