Analytical Applications of Surface-Enhanced Hyper-Raman Scattering

在化学系化学测量和成像项目的支持下，圣母大学的Camden和Svarovsky教授将研究表面增强超拉曼散射（SEHRS）效应的分析应用，并实施一项由学生驱动的项目，以监测地下水源中的铀浓度。 SEHRS是一种提供关于吸附在表面上的分子的独特信息的技术。这项工作的成功有可能影响广泛的研究，特别是在复杂环境中吸附在表面上的分子的几何形状不同。 它还可以在深层组织成像中发挥作用。 此外，Camden和Svarovsky教授及其团队还致力于降低SEHRS光谱仪成本的方法，使SEHRS可用于各种研究人员和分析问题。在这两个实验室工作的学生有很好的机会通过合作学习不同的技能。作为吸引新的全国K-12观众参与外展工作的一种方式，卡姆登教授和斯瓦罗夫斯基教授还计划与圣母大学STEM教育中心合作，推出一个名为U-Watch的新公民科学项目。该计划将带来的好处，基于表面的光谱学研究支持这项赠款，以广大观众，并可以确定潜在的危险水平的污染，如铀，在地下水饮用sources.In这项工作中，SEHRS是用来提供信息，是无法通过其他技术。单分子SEHRS的新方法用于探测复杂化学环境中单分子水平上的纳米颗粒-吸附物相互作用。 SEHRS纳米颗粒还可作为近红外和短波红外（SWIR）（0.8-2.5 Pm）传感，成像和认证的平台。圣母大学的研究小组还计划开发所需的表征方法，以追求SWIR标签的合理设计，并将其应用于深层组织成像研究。 SEHRS和表面增强拉曼光谱（Sers）的比较表明，在某些情况下，SEHRS可以比Sers更灵敏。最后，他们探讨了手持，现场便携式设备能够记录SEHRS光谱与连续波激光的潜力。通过支持的研究，研究小组将证明SEHRS是一种强大而实用的分析方法，用于超灵敏检测，成像以及表面结构和环境的阐明。

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professors Camden and Svarovsky of the University of Notre Dame will undertake a study of the analytical applications of the surface-enhanced hyper-Raman scattering (SEHRS) effect and implement a student-driven program to monitor the concentration of uranium in ground water sources. SEHRS is a technique provide unique information about molecules adsorbed on a surface. The success of this work has the potential to impact a wide range of studies, especially the geometry of a molecule adsorbed on a surface differs in complex environments. It can also make a difference in deep-tissue imaging. Furthermore, Professors Camden and Svarovsky and their groups also work on ways to reduce the cost of SEHRS spectrometers, making SEHRS accessible to a wide range of researchers and analytical problems. Students working in these two labs have a great opportunity to learn different skills through collaboration. As a way to engage a new and national K-12 audience in outreach efforts, Professors Camden and Svarovsky also plan to work with the University of Notre Dame's Center for STEM Education together and launch a new Citizen Science project called U-Watch. The program will bring the benefits of surface-based spectroscopy research supported by this grant to a broad audience and could identify potentially dangerous levels of contamination, such as uranium, in ground water drinking sources.In this work, SEHRS is used to provide information that is not available via other techniques. New methods for single-molecule SEHRS are used to probe nanoparticle-adsorbate interactions at the level of single molecules in complex chemical environments. SEHRS nanoparticles also serve as a platform for near-infrared and short-wave-infrared (SWIR) (0.8-2.5 Pm) sensing, imaging, and authentication. The Notre Dame groups also plan to develop the characterization methods needed to pursue the rational design of SWIR tags and apply them to deep-tissue imaging studies. A comparison of SEHRS and surface-enhanced Raman spectroscopy (SERS) shows that SEHRS can be more sensitive than SERS in certain situations. Lastly, they explore the potential for hand-held, field-portable devices capable of recording SEHRS spectra with continuous-wave lasers. Through the supported research, the groups will demonstrate SEHRS as a powerful and practical analytical approach to ultrasensitive detection, imaging, and the elucidation of surface structure and environment.