Metal Catalyzed Methods for the Preparation of Organosilanes and Related Reactions

这一奖项来自化学系化学合成计划，支持特拉华大学的唐纳德·A·沃森教授的工作。沃森教授正在开发允许合成含有硅原子的新有机分子的方法。这些类型的分子在化学合成和消费品开发中都有广泛的应用，如塑料、不粘涂料和个人护理产品。沃森教授和他的学生正在追求的方法是使这些重要的产品能够从简单、廉价和容易获得的原料中合成出来。沃森教授还在开发一个综合性本科生研究项目，为来自代表性不足群体的学生提供从事尖端化学研究的机会。该项目让学生更好地与自己的研究领域建立联系，为他们提供更多的指导机会，并培养他们的研究技能，以便他们能够在研究生院或未来的就业中脱颖而出。此外，沃森教授和他的研究小组正在开展推广活动，向学龄前和学龄前儿童介绍化学科学。唐纳德·A·沃森教授和他的研究小组正在研究亲电硅试剂(卤化硅化物和三氟化硅)与使用镍和钯催化的碳亲核试剂的使用。Watson小组正在寻求使用直接的交叉偶联方法来合成受阻的烷基、烯丙基和乙烯基硅烷的改进方法。这项工作的目标是与已知工艺相比扩大这些转化的范围，通过设计新的催化系统来提高反应活性，并探索我们开发的转化的机理。沃森教授和他的团队也在探索使用不对称催化剂对这些反应进行立体控制。总体而言，该计划正在为有机硅烷合成带来新的、强大的和有用的方法。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award from the Chemical Synthesis Program in the Division of Chemistry supports the work of Professor Donald A. Watson of the University of Delaware. Professor Watson is developing methods that allow for the synthesis of new organic molecules that contain silicon atoms. These types of molecules have broad application to both chemical synthesis and the development of consumer products such as plastics, non-stick coatings, and personal care products. The methodology being pursued by Professor Watson and his students is enabling the synthesis of these important products from simple, cheap, and readily available starting materials. Professor Watson is also developing an integrated undergraduate research program that provides students from underrepresented groups the opportunity to pursue cutting-edge chemical research. This program is allowing students to better connect with their field of study, offering them increased opportunities for mentorship, and developing their research skills so that they can excel in either graduate school or their future employment. In addition, Professor Watson and his research group are engaging in outreach activities that introduce preschool and early school age children to the chemical sciences. Professor Donald A Watson and his research group are examining the use of electrophilic silicon reagents (silyl halides and triflates) with carbon nucleophiles using nickel and palladium catalysis. The Watson group is seeking improved methods for the synthesis of hindered alkyl-, allyl-, and vinyl-silanes using straightforward cross-coupling approaches. The goal of this effort is to increase the scope of these transformations compared to known processes, increase reactivity though the design of new catalytic systems, and to explore the mechanisms of the transformations we develop. Professor Watson and his group are also exploring stereocontrol in these reactions using asymmetric catalysts. In total, this program is leading to new, powerful, and useful methods for organosilane synthesis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.