Anisotropic light propagation in biological tissue

该项目的目的是基于光与组织微观结构的相互作用来理解光在各向异性生物组织中的传播。在实验研究方面，一些测定组织光学性质的方法将得到改进或新发展。除了角度测量外，直接测定光学性质的准直透射实验和散射光学显微镜研究，如光热测量、空间分辨、时间分辨和角分辨反射和组合测量，将用于间接测定光学性质。对于麦克斯韦方程组的理论描述、解析解和数值解，需要推导、实现和展开辐射传递方程及其近似，如SP_N方程或扩散方程。实验方法需要用不同的组织模型进行验证，理论解需要用替代方法进行验证。所得结果不仅有助于提高生物医学光学领域的治疗和诊断应用，而且为理解不同类型光学显微镜的成像奠定了基础。

The aim of the project is the comprehension of the light propagation in anisotropic biological tissue based on the interaction of light with the microstructure of the tissue. Concerning experimental investigations several methods for determination of the optical properties of tissue will be improved or newly developed. Besides goniometric measurements, collimated transmission experiments and scattering light microscopy investigations for the direct determination of the optical properties, e.g. photothermal measurements, spatially-, time- and angularly-resolved reflection and combined measurements will be applied for their indirect determination. For the theoretical description analytical and numerical solutions of Maxwell's equations, the radiative transfer equation and its approximations, e.g. the SP_N equations or the diffusion equation, shall be derived, implemented and expanded. The experimental methods are to be validated with different tissue phantoms and the theoretical solutions shall be verified with alternative methods. The obtained findings serve not only for the improvement of the therapeutical and diagnostic applications in the field of biomedical optics but are also the base for understanding the image formation for different types of light microscopy.