MRI: Acquisition of Enhanced Mass Spectroscopy Capabilities at Portland State University

该奖项由主要研究仪器和化学研究仪器计划支持。 来自波特兰州立大学的Dirk Iwata-Ekryl教授及其同事Robert Strongin、丹尼尔Ballhorn、大卫斯图尔特和Theresa McCormick获得了一台高性能台式四极轨道阱质谱仪，该质谱仪具有能够进行串联质谱分析的前端离子阱，并配备了真实的时间（DART）源的直接分析。一般来说，质谱（MS）是用于识别和表征复杂基质中少量化学物质的关键分析方法之一。在典型的实验中，组分流入质谱仪，在那里它们被电离并测量离子质量。这种高灵敏度的技术可以检测和确定复杂混合物中分子的结构。DART源用于在大气压和开放实验室环境中快速分析各种样品。此次收购加强了大学和地区的研究基础设施。该仪器通过利用这一现代分析技术让不同的学生参与研究和研究培训，扩大了参与。这是一个多用户、多部门（和多机构）的设施，加强了积极的跨学科活动。参加PSU高级仪器课程的学生接受仪器和使用方面的培训。在旨在扩大妇女和代表性不足的群体参与STEM教育和研究的项目中，有罗纳德E。麦克奈尔学者，加强跨学科的基础设施培训在俄勒冈州，和路易斯斯托克斯少数民族参与联盟。除了该设施为PSU的本科生和研究生提供培训外，附近四年制院校的教师和学生也可以使用该仪器，参与暑期实习的高中科学教师也可以使用该仪器。该提案旨在加强各级的研究和教育。它特别影响了转移RNA中化学修饰核苷的形成和功能的研究，以及分子传感器和探针中氧化还原和发色团材料和机制的研究。该质谱仪用于研究不同营养水平的生物体之间的相互作用，并用于开发使用异配位镍-吡啶硫醇盐催化剂的太阳能燃料发电催化剂。该仪器还帮助研究人员开发与高价二芳基碘试剂的反应，以及那些开发筛选测试和评估具有医疗潜力的新化合物的研究人员。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Dirk Iwata-Reuyl from Portland State University and colleagues Robert Strongin, Daniel Ballhorn, David Stuart and Theresa McCormick have acquired a high-performance benchtop quadrupole orbitrap mass spectrometer with a front-end ion trap that is capable of tandem mass spectrometry, and equipped with a direct analysis in real time (DART) source. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex matrices. In a typical experiment, the components flow into a mass spectrometer where they are ionized and the ion masses are measured. This highly sensitive technique allows detection and determination of the structure of molecules in a complex mixture. The DART source is used for rapid analysis of a wide variety of samples at atmospheric pressure and in the open laboratory environment. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse students in research and research training using this modern analytical technique. This is a multi-user, multi-departmental (and multi-institutional) facility that enhances active interdisciplinary activities. Students enrolled in an advanced instrumentation course at PSU are trained on the instrument and use. Among the programs designed to broaden participation by women and underrepresented groups in STEM education and research are the programs Ronald E. McNair Scholars, Enhancing cross-disciplinary infrastructure training at Oregon, and the Louis Stokes Alliance for Minority Participation. In addition to the training that this facility provides to undergraduate and graduate students at PSU, faculty and students from nearby 4-year institutions also have access to the instrument as do high school science teachers involved in summer internships.The proposal is aimed at enhancing research and education at all levels. It especially impacts studies on the formation and function of chemically modified nucleosides in transfer RNA and investigations on redox and chromophore materials and mechanisms in molecular sensors and probes. The mass spectrometer is used for studies of interactions between organisms of different trophic levels and for developing catalysts for solar fuel generation using hetero-ligated nickel-pyridinethiolate catalysts. The instrument also aids researchers developing reactions with hipervalent diaryliodonium reagents, and those developing screening tests and evaluating new compounds having medical potential.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.