SBIR Phase II: A carbon selective detector for liquid phase chemical detection of organic molecules

这个小企业创新研究（SBIR）第二阶段项目的更广泛的影响/商业潜力是有可能直接和积极地影响化学分析的速度，从而产生更清洁和更先进的产品。由提议的活动产生的技术将解决化学分析行业的几个痛点，包括非线性，小动态范围和可变的，有时可以忽略不计的检测器响应。因此，这项技术将有广泛的应用，并导致在制药、药物开发、燃料、化学、可再生能源、食品、香料以及学术和工业研究中改进检测。火焰电离探测（FID）对碳的均匀响应将彻底破坏已知化合物的艰苦校准方法和与未知化合物定量相关的猜测。这项技术的优势有望极大地提高高效液相色谱（HPLC）分析的速度和准确性，从而以更快的开发时间生产出更好、更安全的产品。应用于制药和新药开发行业，这项技术将对社会的健康和安全产生持久的影响，因为可以更好、更快地进行分析。SBIR二期项目旨在向全球科学市场提供碳选择探测器（CSD）。CSD是一种高效液相色谱（HPLC）检测器，使用火焰电离检测（FID）和催化反应器对所有有机化合物产生线性响应。关键的创新是新开发和使用催化反应器转化有机分子和去除液相色谱仪流出流中的溶剂。FID与气相色谱（GC）系统中普遍存在的FID类似，对转化为甲烷的有机化合物产生普遍的响应，具有无与伦比的线性范围和鲁棒性。通过选择性地去除溶剂，将有机化合物氧化为二氧化碳，将二氧化碳还原为甲烷，并用FID检测生成的甲烷，该装置将克服FID先前在HPLC中使用的局限性。由此产生的产品特征，最显著的是对碳的普遍反应，将为临床前药物研究人员提供一种工具，可以在筛选过程中量化药物及其副产品，而早在该过程被扩大到生产校准标准之前。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is the potential to directly and positively impact the speed of chemical analysis leading to cleaner and more advanced products. Technology resulting from the proposed activity will solve several pain points in the chemical analysis industry, including non-linearity, small dynamic range and variable, sometimes negligible, detector response. As a result, the technology will have broad use and lead to improved detection in pharmaceuticals, drug development, fuels, chemicals, renewables, foods, flavors, and academic and industrial research. Uniform response to carbon from flame ionization detection (FID) would be completely disruptive to the painstaking methods of calibration of known compounds and the guesswork associated with the quantification of unknowns. The benefits of this technology are expected to result in immense improvements in the speed and accuracy of high-performance liquid chromatography (HPLC) analysis, thereby leading to better and safer products, with faster development times. Applied to the pharmaceutical and new drug development industry, this technology will have lasting impacts on the health and safety of society due to better and faster analyses available.This SBIR Phase II project aims to deliver a carbon selective detector (CSD) to the global scientific market. The CSD is a high-performance liquid chromatography (HPLC) detector that produces a linear response to all organic compounds using a flame ionization detection (FID) and a catalytic reactor. The key innovation is the novel development and use of a catalytic reactor to transform organic molecules and remove solvent in liquid chromatograph effluent streams. The FID, similar to those ubiquitous in gas chromatography (GC) systems, yields a universal response to organic compounds converted to methane with unparalleled linear range and robustness. The device will overcome limitations of the FID that have prevented previous use in HPLC by selectively removing solvents, oxidizing organic compounds to carbon dioxide, reducing carbon dioxide to methane, and detecting the resulting methane with the FID. The resulting product features, most notably a universal response to carbon, will provide pre-clinical pharmaceutical researchers with a tool that can quantify drugs and their by-products during screening, long before the process has been scaled up for the production of calibration standards.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.