Multiphase-Separation and Control of Serially Produced Reactive Oxygen

化学结构、动力学和机理- b项目支持纽约城市大学布鲁克林学院Alexander Greer教授的基础研究。格里尔教授开发了精确研究含活性氧物质（通常称为活性氧中间体（ROIs））化学的技术。roi在合成化学中很重要，对于理解生物学和环境中的老化过程至关重要。本研究旨在通过新合成的微粒子和纳米粒子来解决ROI化学中的机理问题。进一步的科学影响来自于设计能够抵抗因暴露于光和氧而引起的老化的材料。该项目支持研究生的培训。Greer教授通过扩大美国光生物学学会的“儿童光生物学”项目，在与布鲁克林学院合作的其他教育努力中，培养STEM人才和对科学的热情，并在更广泛和更年轻的受众中培养科学热情。每年的高中化学日。活性氧中间体（ROIs；氧自由基和单线态氧）在有氧光化学领域很流行，但它们的研究已经被证明是非常困难的。许多主要的光依赖性和次要的roi产生事件仍未定义。目前，光敏化已与传统的生产方法一起使用，例如均相溶液，这导致roi的复杂混合物。本研究旨在了解初始光氧化事件后的下游反应，控制天然和合成分子的氧化，减少对生物体的毒性和对材料的破坏，并开发新的供水消毒方法。这项基础研究也可能导致在垃圾填埋场和海洋中快速光降解塑料的新工艺。研究了光生成活性氧中间体的新非均相方法，通过有效调节反应性来合理操纵roi。该研究提供了一种相分离方法，促进了复杂光化学过程的反褶积。研究主要形成的过氧化物的下游反应的一个关键特征是能够深入了解多阶段氧化事件。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The Chemical Structure, Dynamics and Mechanisms-B Program supports the fundamental research by Professor Alexander Greer at the City University of New York, Brooklyn College. Professor Greer develops techniques for accurately studying the chemistry of reactive oxygen-containing species, often called reactive oxygen intermediates (ROIs). ROIs are important in synthetic chemistry and are critical to understanding the aging processes in biology and in the environment. This research seeks to resolve mechanistic questions in ROI chemistry by using newly synthesized micro- and nanoparticles. Further scientific impact comes from designing materials which are resistant to aging caused by exposure to light and oxygen. The project supports training of research students. Professor Greer cultivates STEM talent and enthusiasm for the sciences within a wider and younger audience by expanding the American Society of Photobiology's program "Photobiology for Kids", among other educational efforts in collaboration with Brooklyn College?s Annual High School Chemistry Day. Reactive oxygen intermediates (ROIs; oxygen radicals and singlet oxygen) are prevalent in the field of aerobic photochemistry, but they have proven extremely difficult to study. Many primary light-dependent and secondary ROIs generation events remain undefined. At present, photosensitization has been used with conventional methods of production, such as homogeneous solution, which leads to complex mixtures of ROIs. This research seeks to understand the downstream reactions that follow initial photooxidation events and to control the oxidation of natural and synthetic molecules, to reduce toxicity to organisms and damage to materials, and to develop new methods for disinfection of water supplies. This fundamental research may also lead to new processes for the rapid photodegradation of plastics in landfills and oceans. New heterogeneous methods for the photogeneration of reactive oxygen intermediates are investigated, allowing the ROIs to be rationally manipulated with effective tuning of reactivity. The research provides a method for phase separation that facilitates the deconvolution of complex photochemical processes. One key feature of studying downstream reactions of primarily formed peroxides is the ability to gain insight into multistage oxidative events.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.