SBIR Phase I: Electric Blower-Based Emergency Mask Ventilator for Simple Ventilation and Monitoring During Patient Distress and Transport

这项小型企业创新研究（SBIR）第一阶段项目的更广泛影响将显着改善需要插管的紧急情况下患者的安全性和结果，这一过程被认为是有缺陷的，但在美国每年进行数百万次。该项目将使急救人员能够使用一种轻便的便携式设备，通过开发一种新设备来测量患者的潮气量或通气周期中通过肺部移动的空气量，从而减少在危急情况下稳定患者的时间。 通过这种测量，响应者将能够更有效，高效和安全地治疗患者。该项目所产生的技术不仅将提高患者的安全性和医疗响应者的效率，而且将以具有成本效益的方式实现这一目标，使买家在经济上可行，以确保每位患者都有这种救命的呼吸支持。拟议项目将进一步开发一种设备，用于测量潮气量，并使用严格控制的压力水平和呼吸率进行呼吸。它将计算和测量潮气量、呼吸频率和每分钟通气量;此外，它将在紧急通气期间动态适应泄漏并检测气道阻塞，为响应者提供即时准确的反馈，并避免对患者造成任何可能的伤害。在这个第一阶段的项目中，我们将通过构建一个紧凑的设备来扩展先前的研究，该设备可以佩戴在响应者的手臂上或吊衣中。 我们将：1）在原型中构建和测试较小的电子器件和传感器; 2）开发先进的监测算法; 3）对患者模拟器进行台架测试以优化系统; 4）进行显示和可穿戴性测试。 该项目的最终目标是提供一个超便携的原型，达到或超过通常用于重症监护病房的呼吸机的性能，扩大对所有需要救生通气的患者的影响。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project will significantly improve the safety and outcomes for patients in emergency situations requiring intubation, a process recognized as flawed, yet performed millions of times per year in the United States. This project will enable responders to use a lightweight, portable device that will decrease the time to stabilize a patient during critical situations by developing a new device to measure the patient’s tidal volume, or volume of air moved through the lungs in a ventilation cycle. With this measurement, responders will be able to treat patients more effectively, efficiently and safely. The resulting technology of this project will not only increase safety for patients and increase efficiency of medical responders, it will do so in a cost-effective manner, making it financially feasible for buyers to assure every patient has this life-saving respiratory support. The proposed project will further develop a device to measure tidal volume and deliver breaths using tightly controlled pressure levels and respiration rates. It will calculate and measure tidal volume, respiratory rate, and minute ventilation; furthermore, it will dynamically adapt to leaks and detect airway obstruction during emergency ventilation, providing instant and accurate feedback to responders and avoiding any possible injury to the patient. In this Phase I project we will extend prior research by building a compact device to be worn on the responder’s arm or in a sling. We will: 1) build and test smaller electronics and sensors in a prototype; 2) develop advanced monitoring algorithms; 3) conduct bench-tests on patient simulators to optimize the system; 4) conduct display and wearability tests. The end goal of this project is to provide an ultra-portable prototype that meets or exceeds the performance of ventilators normally used in intensive care unites, broadening the impact to all patients requiring lifesaving ventilation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.