SBIR Phase I: Automated microfluidic reaction monitoring via miniaturized NMR spectroscopy

这个小企业创新研究第一阶段项目的更广泛/商业影响是开发一种商业上可行的小型化核磁共振（NMR）光谱仪，用于自动小分子监测和分析。该项目旨在解决阻碍核磁共振波谱广泛采用的主要障碍。提出的创新是一个小型化，成本效益高，用户友好的核磁共振系统，从而解决了阻碍广泛采用这种强大的分析方法的主要障碍。它将适合放置在工业制造环境中，为复杂解决方案提供化学计量学见解，从而降低各种高价值生化产品的制造成本。提出的创新构成了具有广泛应用范围的平台技术。拟议的SBIR一期项目将推动核磁共振波谱的发展。所提出的需求点、微流体、按钮式核磁共振光谱仪在大规模生产的硬件小型化、自动化交钥匙设计、多维脉冲序列设计和辅助后处理注释等领域提出了技术挑战。拟议的项目将探索由低仪器灵敏度定义的贸易空间，作为由于磁场强度有限的永磁体的妥协。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader/commercial impact of this Small Business Innovation Research Phase I project is to develop a commercially-viable miniaturized nuclear magnetic resonance (NMR) spectrometer for automated small molecule monitoring and analysis. The project aims to address major obstacles preventing widespread adoption of NMR spectroscopy. The proposed innovation is a miniaturized, cost-effective, and user-friendly NMR system, thus addressing major obstacles preventing widespread adoption of this powerful analytical method. It will be suitable for placement in industrial manufacturing environments to provide chemometric insights on complex solutions, resulting in reduced manufacturing costs for a wide range of high-value biochemical products. The proposed innovation constitutes a platform technology with a broad range of applications.The proposed SBIR Phase I project will be to advance the development of NMR spectroscopy. The proposed point-of-need, microfluidic, push-button NMR spectrometer presents technical challenges in the areas of hardware miniaturization for mass production, automated turnkey design, multidimensional pulse sequence design, and assisted post-processing annotation. The proposed project will explore the trade space defined by low instrument sensitivity, as a compromise due to permanent magnets with limited magnetic field strengths.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.