Hypervalent Iodine Based Materials

在化学系大分子、超分子和纳米化学项目的资助下，南伊利诺伊大学卡本代尔分校的凯尔·N·普朗科特教授正在基于含有化学元素碘的有机环分子创造新的超分子组件。受自然的启发，超分子化学利用氢键来决定蛋白质、酶和DNA等组件。在这项研究中，开发了基于含碘片段的氨基酸为组装准备构建块的一般策略。这些构建块为3D结构提供了一个框架，这些结构在气体/分子吸收和传感方面有应用。用几种实验技术研究了成键和性能。该项目有助于培训不同的学生群体。研究团队正在设计180度实验室实验和演示的3D视频。视频内容与虚拟现实耳机一起使用，让联网的学习者沉浸在虚拟的化学世界中。外展活动的重点是招募当地高中生参加暑假、寒假或春假期间的研究活动。这项研究的重点是开发基于氨基酸功能化苯并咪唑合成的高价碘大环的新的超分子组件。这些分子通过二次键自组装成大环结构，这些大环结构是包括分子笼和共价有机骨架在内的高阶超分子结构的基石。这些宏观结构提供了一个框架，通过非天然氨基酸侧链的连接来构建分子笼子。这项工作的具体目标是探索高价碘大环的动态共价键，并确定通向分子笼的方便的合成路线。研究人员还试图量化客体离子/分子结合亲和力、反应促进的分解和固态性质，并基于高价碘大环化反应表征共价有机框架。这项研究提供了指导超分子组装的新方法，这一点非常重要，因为新的成键和反应可能性可以提供手性识别和反应性等性质的途径。此外，这项研究的潜在影响包括设计和合成高表面积材料，这些材料具有在气体/分子吸收和传感方面的新特性。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

With funding from the Macromolecular, Supramolecular, and Nanochemistry Program of the Chemistry Division, Professor Kyle N. Plunkett of Southern Illinois University at Carbondale is creating new supramolecular assemblies based on organic cyclic molecules that contain the chemical element iodine. Inspired by nature, supramolecular chemistry utilizes hydrogen bonding to dictate assemblies such as proteins, enzymes, and DNA. In this research, general strategies are developed to prepare building blocks for assemblies based on amino acids containing iodine fragments. These building blocks provide a framework for 3D structures that have applications in gas/molecular absorption and sensing. The bonding and properties are investigated using several experimental techniques. This project contributes to the training of a diverse group of students. The research team is designing 180-degree 3D videos of laboratory experiments and demonstrations. The video content is used with virtual reality headsets to immerse internet-connected learners in a virtual chemistry world. Outreach activities focus on recruitment of local high school students to participate in research stays over the summer, winter or spring breaks.This research is focused on developing new supramolecular assemblies based on hypervalent iodine macrocycles that are synthesized from amino acid functionalized benziodazoles. These molecules self-assemble through secondary bonding into macrocyclic structures, which are the building block for the higher order supramolecular structures including molecular cages and covalent organic frameworks. These macrostructures provide a framework to build molecular cages by linkages made through non-natural amino acid side chains. Specific goals of this work are to explore the dynamic covalent bonding of hypervalent iodine macrocycles and identify expedient synthetic routes towards molecular cages. The investigators also seek to quantify guest ion/molecule binding affinity, reaction-promoted disassembly and solid-state properties and characterize covalent organic frameworks based on hypervalent iodine macrocyclization reactions. This research provides new methods to guide supramolecular assemblies, which is of fundamental interest because of the new bonding and reactivity possibilities that could provide access to properties such as chiral recognition and reactivity. Additionally, potential impacts of this research include the design and synthesis of high surface area materials that have emerging properties for applications in gas/molecule absorption and sensing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.