MRI: Acquisition of an Advanced Confocal Microscope System for Research and Research Training at San Francisco State University

旧金山州立大学(SFSU)被授予购买先进的激光点扫描共聚焦显微镜系统，用于该拉美裔服务机构(HSI)的不同学生(44%来自历史上代表性不足(HU)群体，50%来自低收入群体，48%第一代大学生，57%女性)的研究和研究培训。这台仪器的新功能将设在旧金山州立大学的细胞和分子成像中心，它将使学生成为尖端技术方面的专家，这对在竞争激烈的博士课程和生物技术行业取得成功至关重要。使用该系统的学生还将出现在由上海外国语大学本科生撰写的科学家聚光灯中。这些聚光灯展示了不符合经典刻板印象的科学家，并提供了鼓舞人心和相关的近同行榜样，以及不同的本地科学家在STEM中参与K-12学生和公众的例子。该系统的先进功能也将使暑期研究培训课程能够在SFSU举办，以扩大更多SFSU本科生进行研究的机会，这是一个与学位完成密切相关的因素。共焦显微镜系统将影响广泛的、跨学科的研究项目。来自旧金山州立大学生物、化学和生物化学、物理学和运动学系的15名研究人员将使用该仪器进行细胞和发育生物学、生理学和材料科学的研究。该仪器将能够跟踪和量化细胞动力学的分子特征的变化，包括线虫中的染色体分离，酵母和果蝇中的细胞器遗传和大小调节，以及细菌、植物和哺乳动物细胞中的亚细胞蛋白质定位。该仪器的特点将使检测刺激诱导的哺乳动物发育所需的信号分子的变化以及分析纳米材料中广泛的低水平荧光成为可能。该系统将支持旧金山州立大学的研究人员进行相关和有影响力的研究，并在同行评议的期刊文章和科学会议上的演讲中传播他们的新发现。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

An award has been made to San Francisco State University (SFSU) to purchase an advanced Laser Point-Scanning Confocal Microscope system for research and research training of the diverse students (44% from historically under-represented (HU) groups, 50% low income, 48% 1st generation college students, and 57% women) at this Hispanic Serving Institution (HSI). The new capabilities of this instrument, which will be housed in the Cell and Molecular Imaging Center at SFSU, will enable students to become experts in state-of-the-art technology, which is critical for success in highly competitive doctoral programs and the biotechnology industry. Students using the system will also be featured in Scientist Spotlights authored by SFSU HU undergraduates. These spotlights showcase scientists that do not conform to classic stereotypes and provide inspiring and relevant near-peer role models as well as examples of diverse, local scientists to engage K-12 students and the public in STEM. The advanced features of the system will also enable summer research training courses to be held at SFSU to broaden opportunities for more SFSU undergraduates to conduct research, a factor closely tied to degree completion. The confocal microscopy system will impact a broad, interdisciplinary range of research projects. Fifteen investigators from the Biology, Chemistry & Biochemistry, Physics, and Kinesiology Departments at SFSU will use the instrument to conduct studies in cell and developmental biology, physiology, and materials science. The instrument will enable tracking and quantification of changes in molecular features of cellular dynamics, including chromosome segregation in C. elegans, organelle inheritance and size regulation in yeast and Drosophila, and subcellular protein localization in bacteria, plant, and mammalian cells. Features of the instrument will enable detection of stimulus-induced changes in signaling molecules required for development in mammals as well as the analysis of a broad spectrum of low-level fluorescence in nanomaterials. The system will support SFSU researchers to conduct relevant and impactful research and disseminate their new discoveries in peer-reviewed journal articles and presentations at scientific conferences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.