Untersuchungen zur hormonellen Modulation dopaminerger Mechanismen von impulsivem Verhalten (B03)

在我们之前工作成果的基础上，我们项目的第二阶段将专注于将各种生物因素整合到稳态机制和奖励相关信号之间相互作用的电路模型中。这些模型将结合人类神经成像和行为数据的生成模型的最新进展，以及在稳态和奖励处理的实验扰动期间的遗传、代谢、内分泌和免疫学分析。重点将是获得关于在不同饱腹状态下控制食物选择的稳态和情感（享乐）价过程的紧凑、易于处理的网络动力学指数。

Building on the achievements of our previous work, the second phase of our project will focus on integrating the various biological factors into circuit models of interactions between homeostatic mechanisms and reward-related signals. These models will combine recent advances in generative modelling of human neuroimaging and behavioural data with genetic, metabolic, endocrine, and immunological analyses during experimental perturbations of homeostasis and reward processing. A focus will be on obtaining compact, tractable indices of network dynamics with regard to homeostatic and affective (hedonic) valence processes that govern food choice in different states of satiety.