Enantioselective Conversion of Achiral Diketones and Triketones for Shortened Bioactive Molecule Synthesis

对新的和更复杂的对映纯药物的不断需求使得对映选择性有机方法成为一个高增长的领域，并得到学术资助机构的支持。在这种背景下，发现和发展可持续的对映选择性方法（减少环境影响化学）是化学领域当前和不断增长的主题。在这种情况下，水是一种有趣的溶剂，因为它的可用性和发展绿色方法的潜力。该项目符合上述主题，并要求开发有前途的有机催化剂，用于醛醇和相关反应。该项目的未来目标是在减少对环境影响的情况下，为药物和天然产物的合成提供更大的设计灵活性，提高效率。

The constant demand for new and more complex enantiopure pharmaceutical drugs has made enantioselective organic methodology a high growth area, which is supported by academic granting agencies. In this context, the discovery and development of sustainable enantioselective methods (reduced environmental impact chemistry) is a current and ever increasing theme within chemistry. In this context water is an interesting solvent because of its availability and potential for allowing the development of green methods. This project fits into the above noted themes and is a request to develop promising organocatalysts for aldol and related reactions. The forwarding looking goal of this project is to allow greater design flexibility with improved efficiency for the synthesis of pharmaceutical drugs and natural products with reduced environmental impact.