SBIR Phase I: Integrated Manufacturing of Artificial Valves for Medical Use

这项小企业创新研究（SBIR）一期项目的广泛影响是改善需要血管（静脉）或泌尿系统瓣膜的患者的临床结果。人工制造流体控制元件（如阀门）是很困难的，因为它们具有生物相容性，能够承受与它们的功能相关的物理力，以及与衰老相关的不断变化的环境。本课题提出了一种制造人工无缝线装置的系统。该项目将优化制造聚合物阀门的材料和变量，该阀门集成了耐用的聚合物封装结构镍钛诺框架。这种镍钛醇聚合物结构必须能够承受长期的体内条件挑战，同时保持物理界面，不会过早分层和设备功能丧失。聚氨酯材料具有优异的机械性能，在植入物中具有严格的应用和使用历史。该项目探索了这些阀门大规模制造和部署的相关参数的相空间。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to improve clinical outcomes for patients needing valves for vascular (veins) or urinary systems. It is difficult to make artificial versions of the fluid control elements, such as valves, that are biocompatible and withstand the physical forces associated with their function, as well as the changing environment associated with aging. The proposed project advances a system to make artificial sutureless devices.The proposed project will optimize the materials and variables of manufacturing a polymer valve integrated with durable polymer encapsulation of a structural Nitinol frame. This Nitinol-polymer structure must withstand long-term challenging in vivo conditions while maintaining a physical interface that does not experience premature delamination and loss of device functionality. Polyurethane materials have excellent mechanical properties for rigorous applications and history of use in implants. This project explores the phase space of relevant parameters for manufacturing and deployment of these valves at scale.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.