I-Corps: Transimpedance amplifier (TIA) for sensing systems that converts sensor current to voltage and amplifies the signal

I-Corps项目的更广泛影响/商业潜力是开发小型便携式医疗设备技术，以改善患者的生活质量。当前医疗保健中的护理点技术通常很麻烦，需要反复充电、大面积/容量和许多设备组件。该技术减少了器件的数量，功耗更低，重量轻，同时提高了测量灵敏度。最初提出的应用是测量糖尿病患者血糖水平的变化。此外，该设计还可用于其他传感应用，如疾病跟踪和其他医疗监测、物联网、可穿戴电子产品、射频收发器、光电探测器、军事和空间应用、脑电图（EEG）、微陀螺仪、生物混合机器人和心电图（ECG）。这个I-Corps项目是基于集成电路的发展，可以提高需要低功率和经历低噪音或干扰的设备的响应信号。基于技术模型、仿真和生物传感输入数据，与目前市场上用于监测系统的集成电路相比，该设计有望提供更准确的器件响应，表现出低输入阻抗、低输入参考噪声电流、低功耗、低噪声、高跨阻增益，并在低电压下工作。例如，该技术集成了一个信号放大装置（跨阻抗放大器，TIA），将葡萄糖水平的变化转换为更精确的可测量信号。此外，该装置可用于许多不同的传感应用。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of small, portable technology for medical devices to improve the quality of life for patients. Current point-of-care technology in healthcare is often cumbersome, requiring repeated charging, large area/capacity, and many device components. The proposed technology reduces the number of device components, uses less power, and is lightweight while enhancing the measurement sensitivity. The initial proposed application is to measure changing glucose levels for diabetic patients. In addition, this design may be used for other sensing applications, such as disease tracking and other healthcare monitoring, the internet of things, wearable electronics, RF transceivers, photodetectors, military and space applications, electro-encephalograms (EEG), microgyroscopes, biohybrid robotics, and electro-cardiographs (ECG).This I-Corps project is based on the development of integrative circuitry that may boost the response signal of devices requiring low power and experiencing low noise or interference. Based on technical models, simulations, and biosensing input data, the designs are expected to provide more accurate device responses, exhibit low input impedance, low input-referred noise current, low power consumption, low noise, high transimpedance gain, and operate at low voltage compared with current market integrated circuits for monitoring systems. For example, this technology integrates a signal amplification device (transimpedance amplifier, TIA) that will convert the change of glucose levels to a more accurate measurable signal. In addition, this device may be used for many different sensing applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.