Borylative Heterocyclization Reactions

在化学系化学合成(SYN)项目的支持下，加州大学欧文分校的Suzanne A.Blum教授将与研究生一起设计新的化学反应，使分子含有硼。这些含硼的新分子在药物发现和构建下一代先进材料方面的应用非常重要。在这项研究中，将开发新的化学方法，在分子中目前不可能的位置插入硼。同时，还将获得关于如何操纵化学反应在分子中理想但目前无法获得的位置插入硼的基本知识。由此积累的基础知识可能会对与硼的化学反应的发展做出贡献，远远超出本研究项目的范围。通过设立教师职业研讨会和圆桌会议系列，将产生更广泛的影响和社会效益。布鲁姆教授将与研究生一起开发新的硼/元素加成反应。这些反应产生的产物将是对药物发现和材料合成有用的硼化有机构建块。这种化学反应是通过硼化杂环化反应将硼/氧、硼/氮和硼/硫加成到碳-碳键上。同时进行的机理研究有望产生关于中间体在这些转化中的反应性的基础知识，这适用于开发反应设计。这些研究将汇集Blum教授实验室在有机合成、有机金属化学、机理研究和反应开发方面的不同专业知识，以解决这些具有挑战性的科学实验。布鲁姆教授在加州大学欧文分校(UCI)成功的未来教师培训计划的扩大，对社会产生了额外的更广泛的影响。这一计划将为创建教师职业研讨会提供独特的条件，它将解决UCI研究生和博士后学者在其他方面未得到满足的专业发展需求。具体地说，研讨会和圆桌会议系列将为研究生和博士后学者提供网络、教育和指导机会，包括传统上代表不足的群体参与科学的重点机会。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

With the support of the Chemical Synthesis (SYN) program in the Division of Chemistry, Professor Suzanne A. Blum of the University of California, Irvine, will work with graduate students to design new chemical reactions that make molecules containing boron. These new molecules with boron are important for applications in drug discovery and the construction of the next generation of advanced materials. In this research, new chemical methods will be developed, which insert boron at positions in molecules that are not currently possible. Concurrently, fundamental knowledge will be gained about how to manipulate chemical reactions to insert boron at desirable, but currently unobtainable, positions in molecules. The fundamental knowledge thereby accrued will likely contribute to chemical reaction development with boron well beyond this research project. Additional broader impacts and societal benefits will be achieved through the creation of a Careers in Teaching seminar and roundtable series. Professor Blum will work with graduate students to develop new boron/element addition reactions. The products arising from these reactions will be borylated organic building blocks that are useful for drug discovery and materials synthesis. This chemistry is directed at the addition of boron/oxygen, boron/nitrogen, and boron/sulfur to carbon–carbon bonds through borylative heterocyclization reactions. Concurrent mechanistic studies are expected to generate fundamental knowledge about the reactivity of intermediates in these transformations that is suitable for developing reaction design. These studies will bring together the diverse expertise of Professor Blum’s laboratory in organic synthesis, organometallic chemistry, mechanistic investigation, and reaction development to address these challenging scientific experiments. The expansion of the Professor Blum’s successful future faculty teacher training program at the University of California, Irvine (UCI) forms an additional broader impact for society. The creation of a Careers in Teaching Symposium will be uniquely enabled by this program and it will address an otherwise unmet need for the professional development of graduate students and postdoctoral scholars at UCI. Specifically, a seminar and roundtable series will provide graduate students and postdoctoral scholars with networking, education, and mentorship opportunities, including focused opportunities for participation of traditionally underrepresented groups in the sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.