Green and Sustainable Catalysts for Synthesis of Organic Building Blocks

在前期研究成果的基础上，我们设想建立以氧为末端氧化剂的铁催化各种底物的脱氢homo-和交叉偶联反应。特别是芳基/芳基、芳基/乙烯基、芳基/烷基和苄基/苄基交叉偶联反应将是本项目的重点。探讨了使用手性铁催化剂和/或手性添加剂进行不对称合成的可行性。新建立的方法将应用于有机合成构件和选定的天然产物的合成。此外，我们将研究铁催化的选择性氧化和氮化反应，包括C(sp3) -氢键活化。另一个目标是将我们的铁催化瓦克反应应用于天然产物的合成。设计新型铁配合物，为设想的转化生成微调催化剂，是该项目的关键要素。

Based on the results of the previous funding period, we envisage to establish iron-catalyzed dehydrogenative homo- and cross-coupling reactions of various substrates using oxygen as terminal oxidant. In particular, aryl/aryl, aryl/vinyl, aryl/alkyl and benzyl/benzyl cross-coupling reactions will be in the focus of this project. The feasibility of asymmetric syntheses will be explored using chiral iron catalysts and/or chiral additives. The newly established methods will be applied to the synthesis of organic synthetic building blocks and of selected natural products. In addition, we will investigate iron-catalyzed selective oxygenation and nitrogenation reactions including C(sp3)–H bond activation. Another goal is the application of our iron-catalyzed Wacker-type reaction to the synthesis of natural products. The design of novel iron-complexes to generate fine-tuned catalysts for the envisaged transformations is a crucial element of this project.