CAREER: CAS: Red-light mediated photoredox catalysis by helical carbenium ions

该奖项全部或部分由《2021年美国救援计划法案》（公法117-2）资助。在化学系化学催化项目的支持下，亚利桑那大学的Thomas Gianetti正在研究一类新型的有机光催化剂。光催化剂是一种将光转化为化学能并促进化学反应的分子。该项目旨在开发稳定的有机离子，可以利用低能红光促进化学转化。将无金属、无毒的有机光催化剂与丰富、安全的红光光源相结合，有望为精细化学品和药品的合成提供更安全、更环保、更可持续的合成方法。这一职业发展项目的外联活动旨在发展和扩大科学、政策和法律之间前沿的一门新的跨学科课程。该课程将涉及STEM（科学、技术、工程和数学）和非STEM本科生，通过研究与公共政策和日常现代生活中科学结合相关的挑战。本课程将由亚利桑那大学理学院和法学院合作教授和开发。在化学系化学催化项目的支持下，亚利桑那大学的Thomas Gianetti正在研究利用螺旋和稳定的碳正离子作为一种新型的光氧化还原平台来促进化学转化。这些融合的杂环螺旋离子具有固有的螺旋手性和强吸收红光等令人着迷的特性。这里的化学反应是通过光活性还原（中性自由基）或氧化（自由基）类似物进行的。Giannetti博士和他的研究团队将努力探索和发展诸如驱动大规模红光介导转化，建立对映选择性光催化的条件，以及探索多光子激发以获得高度光还原或光氧化的物种等概念。这些活动将为亚利桑那大学的研究生和本科生提供合成化学、光物理和光催化方面的培训。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2).With the support of the Chemical Catalysis Program in the Division of Chemistry, Thomas Gianetti of the University of Arizona is studying a novel class of organic photocatalysts. A photocatalyst is a molecule that converts light into chemical energy and facilitates chemical reactions. This project aims to develop stable organic ions that can utilize low-energy red light to promote chemical transformations. Coupling metal-free and non-toxic organic photocatalysts with abundant and safe red light sources holds promise to provide for safer, greener, and more sustainable synthetic methodologies for the synthesis of fine chemicals and pharmaceuticals. The outreach activity for this CAREER project aims to develop and expand a new interdisciplinary course at the frontier between science, policy and the law. The course will engage both STEM (Science, Technology, Engineering and Mathematics) and non-STEM undergraduate students by examining the challenges relevant to the incorporation of science in public policy and everyday modern life. This curriculum will be taught and developed as a partnership between the College of Science and the School of Law at the University of Arizona.With the support of the Chemical Catalysis Program in the Division of Chemistry, Thomas Gianetti of the University of Arizona is studying the use of helical and stable carbocations as a novel photo-redox platform to promote chemical transformations. These fused heterocyclic helicenium ions have fascinating properties such as possessing inherent helical chirality and strongly absorbing red light. The chemistry here proceeds through photo-active reduced (neutral radical) or oxidized (radical dication) analogues. Dr. Giannetti and his research team will endeavor to explore and develop concepts such as driving large-scale red light-mediated transformations, established conditions for enantioselective photocatalysis, and exploring multi-photon excitation to access highly photo-reducing or photo-oxidizing species. These activities will provide training in synthetic chemistry, photophysics, and photocatalysis for a diverse group of graduate and undergraduate students at the University of Arizona.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.