SONS - Biofunctional Self-Organized Nano-Structures of ionic/non-ionic amphiphilic copolymers, biopolymers-biomacromolecules and nanoparticles: from bioinspired to biointegrated systems

BIOSONS的目标是开发新一代自组装材料和儿子。从公认的自组装嵌段共聚物的基本原理出发，BIOSONS将在这一领域介绍在生物系统中可以找到的非凡资源。这一新模式的方法被设计为三个阶段，通过这三个阶段，合成聚合物的作用逐渐被复杂的生物分子所取代。首先，生物功能(通过选定的多肽和寡核苷酸)将与自组装合成聚合物偶联，作为提高其(生物)功能的一种方式。其次，从天然蛋白质和寡核苷酸中提取的自组装和选择性结合部分也将与合成聚合物结合，以提高它们自组装和显示特定相互作用的能力。在最后阶段，将专门使用具有明显增强的自组装和(生物)功能的生物复合材料。最先进的聚合物合成技术，以及开创性的、面向材料科学的生物技术(基于蛋白质的遗传工程聚合物和经过工程的天然蛋白质和多核苷酸)将成为突破性先进智能、功能和自组装材料的来源。此外，最新的物理化学表征工具--操纵和理论建模，适用于将与生物有关的分子纳入材料和系统所带来的新挑战，将补充合成工作。通过这种真正的多学科方法，随着复杂生物资源的决定性整合，将(生物)生产和操纵更复杂、定义良好的(生物)功能材料，以达到自组装大分子的自组装能力和功能的新标准。预计BIOSONS将在结构和功能方面取得突破性的软、硬子，并为自组装材料科学和工程的理论和方法概念提供新的背景。

BIOSONS aims to the development of a new generation of self-assembling materials and SONS. Starting from the well established rationale for self-assembling block copolymers, BIOSONS will introduce, in this field, the extraordinary resources that can be found in biological systems. The approach to this new paradigm is designed in three stages by which the role of synthetic polymers is progressively substituted by sophisticated biological molecules. First, biological functions ( by selected peptides and oligonucleotides) will be coupled to self-assembling synthetic polymers as a way to boost their (bio)functionality. Second, self-assembling and selective-bindings parts taken from natural proteins and oligonucleotides, will be also combined with synthetic polymers to improve their capabilities to self-assemble and show specific interactions. In the last stage, biological complex materials, having clearly enhance capabilities for both, self-assembly and (bio)function, will be exclusively employed. The most advanced polymer synthesis technologies, as well as pioneer, material science-oriented, biotechnology (genetically engineered protein-based polymers and engineered natural proteins and polynucleotides) will be the source of breakthrough advanced smart, functional and self-assembling materials. In addition, the most up-to-date tools of physical-chemical characterization-manipulation and theoretical modelling, adapted for the new challenges brought about by the incorporation of bio-related molecules to the materials and systems, will complement the synthetic effort. By this truly multidisciplinary approach and with the decisive incorporation of sophisticated biological resources, much more complex, well defined and (bio)functional materials will be (bio)produced and manipulated to achieve a new standard in the self-assembling capabilities and functionalities of self-assembling macromolecules. Breakthrough soft and hard SONS, in terms of structure and function, are expected to be obtained in BIOSONS as well as new background of theoretical and methodological concepts in self-assembling material science and engineering.