Are Stereoelectronic Effects Additive or Cooperative? (A09)

立体电子效应在自然界中含量丰富，也是有机化学中的关键元素。该项目的目标是探索立体电子效应是相加的还是协同的。为此，将研究由具有定义构型的CHF实体构建的各种多邻位氟烷烃。这些鲜为人知的功能最终将被整合到具有催化和生物意义的化合物中。该项目的实现需要在SFB的框架内采用多学科方法：综合和结构分析将对WWU Münster的分析机构提出挑战，并将使用计算化学来理解和量化所涉及的相互作用。最后，这些新化合物将应用于对映体选择性催化。

Stereoelectronic effects are abundant in nature and are also key elements in organic chemistry. The goal of the project is to explore whether stereoelectronic effects are additive or cooperative. To this end, various multi-vicinal fluorinated alkanes which are constructed from CHF-entities with defined configuration will be studied. These little explored functionalities will eventually be incorporated into catalytically and biologically interesting compounds. Realization of this project demands for a multidisciplinary approach within the frame of the SFB: syntheses and structural analysis will challenge the analytical institutions of the WWU Münster and also computational chemistry will be used to understand and quantify the addressed interactions. Finally, the novel compounds will be applied to enantioselective catalysis.