Conference: 2022 International Conference on ESCRT Biology

会议旨在为国际和国内研究一组蛋白质(ESCRT蛋白质)提供一个独特的开放、包容和互动的论坛，这些蛋白质调节细胞生物学的许多基本功能。会议将为所有与会者提供一个有效的学习环境，特别是本科生和研究生，以及博士后研究员。参与者还将有很好的机会与来自非常不同学科和生物学领域的研究人员交往，他们都被对ESCRT结构和功能的共同兴趣吸引在一起。NSF的资金将用于增加年轻研究人员的参与广度。会议将包括口头陈述、海报会议和非正式讨论时间。这次会议的具体目标是：1)提供一个开放和包容的论坛，供不同职业层次的研究人员进行口头陈述。将有充足的时间进行讨论。2)为所有参与者，特别是科学领域代表性不足群体的参与者提供机会，在晚间海报会议上介绍和讨论他们的成果。3)通过分享食物和社会活动提供大量的网络和社交互动机会。运输所需的内体复合体(ESCRT)机制由不同的因子(人类约30个蛋白质，植物45个蛋白质)组成，在整个细胞内执行膜重塑和裂变反应。在过去的十年里，已知的ESCRT介导的过程的数量激增，包括内体蛋白运输、细胞动力脱落、有丝分裂后核膜的关闭、被膜病毒的萌发、外体生物发生、神经元修剪和膜修复。此外，最近在古菌和细菌中发现了类似ESCRT的系统，使其成为自然界最保守的机器之一。因此，ESCRT生物界继续增长。尽管取得了这些进展，但许多基本问题仍然没有得到解答，包括ESCRT机制如何限制和介导膜分裂，以及许多ESCRT介导的过程的生物学机制和后果。因此，再次成熟的时机是将我们社区的不同部分聚集在一起，以确保生物物理学家与细胞生物学家交谈，生物化学家向植物生物学家学习，等等。为此，我们提议召开一次多学科会议，涵盖ESCRT生物学的所有关键方面，并将包括以下主题的会议：1)ESCRT介导的膜裂变的生物物理学，2)细丝介导的膜重塑的进化，3)细胞分裂中的ESCRT，4)膜修复中的ESCRT，5)疾病中的ESCRT，以及6)其他系统(植物，古生菌)中的ESCRT机制。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The meeting aims to provide a unique open, inclusive, and interactive forum for the international and domestic research community working on a group of proteins (ESCRT proteins) that regulate many basic functions of cell biology. The conference will provide an effective learning environment for all participants, especially undergraduate and graduate students, and postdoctoral fellows. Participants will also have great opportunities to mix with researchers from very different disciplines and fields of biology who are all drawn together by a common interest in ESCRT structures and functions. NSF funds will be used to increase the breadth of participation of young researchers. The meeting will include oral presentations, poster sessions, and time for informal discussions. The specific objectives of this conference are: 1) To provide an open and inclusive forum for oral presentations from researchers at all levels of their careers. Ample time will be devoted for discussion. 2) To provide an opportunity for all participants, specially to those from under-represented groups in science, to present and discuss their results in evening poster sessions. 3) To offer ample opportunities for networking and social interactions through shared meals and social activities.The Endosomal Complexes Required for Transport (ESCRT) machinery comprises different factors (~30 proteins in humans; 45 in plants) that carry out membrane remodeling and fission reactions throughout the cell. The past decade has seen an explosion in the number of processes now known to be ESCRT-mediated, including endosomal protein trafficking, cytokinetic abscission, closure of the post-mitotic nuclear envelope, enveloped virus budding, exosome biogenesis, neuronal pruning, and membrane repair. Furthermore, ESCRT-like systems have recently been discovered in archaea and bacteria, making this one of the most highly conserved machines in nature. As a result, the ESCRT biology community continues to grow. Despite these advances, a number of fundamental questions remain unanswered, including exactly how the ESCRT machinery constricts and mediates membrane fission, and the biological mechanisms and consequences of many ESCRT-mediated processes. The time is therefore again ripe to bring together the different segments of our community to ensure that biophysicists are talking to cell biologists, biochemists are learning from plant biologists, and so forth. Toward this end, we propose a multidisciplinary conference that will cover all key aspects of ESCRT biology and will include sessions on the following topics: 1) The biophysics of ESCRT-mediated membrane fission, 2) The evolution of filament-mediated membrane remodeling, 3) ESCRTs in cell division, 4) ESCRTs in membrane repair, 5) ESCRTs in disease, and 6) ESCRT machinery in other systems (plants, archaea).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.