CAREER: Frequency Comb-Based Multidimensional Coherent Spectroscopy and Microscopy at the Nanoscale

在化学系化学测量和成像(CMI)计划的支持下，圣克拉拉大学的Bachana Lomsadze正在开发一种新的工具，将近场光学显微镜与频率梳多维相干光谱相结合，以提高超分辨率成像的光谱和空间分辨率，以便更好地了解二维材料的化学和物理性质。了解小尺度下的材料性质对于关联结构变化如何影响化学反应和特异性以及局部能量转移至关重要。洛姆萨泽博士和他的团队正在开发一种新工具，该工具可以提供有关二维过渡金属二卤化物的空间和光谱分辨的化学和物理信息。他们的发现可能会导致在单个粒子水平上更好地了解材料的化学和物理性质，帮助开发量子设备，并在实验室之外找到化学传感或生物医学成像等应用的用途。洛姆萨泽博士还在为非理科专业的学生开发课堂活动，帮助学生理解和欣赏当今影响社会的基础科学和技术。洛姆萨泽实验室将把近场光学显微镜与频率梳多维相干光谱相结合，以提高红外光谱区域二维材料的超分辨率成像的光谱和空间分辨率。虽然目前的方法可以成功地常规地评估二维材料的化学和物理性质，但大多数方法都受到大信号背景、采集时间慢、空间分辨率或光谱分辨率的限制。Lomsadze团队正在开发有可能产生每个像素的二维相干光谱的方法，这些光谱在几秒钟内收集，具有高(即数十纳米)空间分辨率和梳状光谱分辨率。空间和光谱分辨率的这些改进可能导致有关材料的化学、物理和光学性质的新信息，涉及从取证到生物医学成像和现场分析的许多领域。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

With support from the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry, Bachana Lomsadze from Santa Clara University is developing a new tool that combines near-field optical microscopy with frequency comb multidimensional coherent spectroscopy to improve both the spectral and spatial resolutions for super resolution imaging for better understanding of the chemical and physical properties of two dimensional materials. Understanding material properties at small length scales is critical for correlating how structural variations influence chemical reactions and specificity as well as energy transfer locally. Dr. Lomsadze and his group are developing a new tool that provides spatially and spectrally resolved chemical and physical information about the two-dimensional transition metal dichalcogenides. Their discoveries could lead to better understanding of the chemical and physical properties of materials on a single particle level, aid efforts to develop quantum devices, and find use outside the laboratory for applications such as chemical sensing or biomedical imaging. Dr. Lomsadze is also developing classroom activities for non-science majors to help students understand and appreciate basic science and technology that is impacting society today.The Lomsadze lab will combine a near-field optical microscope with frequency comb multidimensional coherent spectroscopy with an eye toward improving the spectral and spatial resolution for super resolution imaging of two dimensional materials in the infrared spectral region. While current methods can successfully evaluate the chemical and physical properties of two dimensional materials routinely, most methods are limited by large signal backgrounds, slow acquisition times, spatial resolution, or spectral resolution. The Lomsadze group is developing methods that have the potential to result in two-dimensional coherent spectra per pixel, that are collected in seconds, with high (i.e., tens of nm) spatial resolution, and with comb spectral resolution. These improvements in spatial and spectral resolution could lead to new information about the chemical, physical, and optical properties of materials with implications in many fields ranging from forensics to biomedical imaging and field analysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.