Development of novel asymmetric domino reactions through the utilization of multiple transition metal catalysts cooperatively in one pot reactions

本博士后研究涉及多个过渡金属催化剂在一个反应罐中合并，以实现对映选择性多步多米诺反应。随着传统分步有机合成的成本和化学废物的不断增加，提高反应效率的能力，特别是在一锅操作中通过多催化多米诺反应形成碳碳键的效率越来越受到科学界的关注。然而，文献已知的多催化系统是非常有限和具有挑战性的，因为不同金属催化剂在时间解决多米诺骨牌方式下的配体特异性和特定官能团活化在这种系统中是至关重要的。本研究旨在利用铑/金或铑/钯对不同官能团进行正交活化，为新兴的多金属多米诺反应领域开辟新的策略。据设想，这种单罐多金属多米诺骨牌策略的成功实施将使生物和工业上有趣的对映体选择性支架更有效地进入。

This postdoctoral research involves the merging of multiple transition metal catalysts within a single reaction pot to effect multistep domino reactions enantioselectively. With the ever increasing cost and chemical waste generated due to traditional stepwise organic synthesis, the ability to improve the efficiency of reactions, especially those forming carbon carbon bonds through multicatalytic domino reactions within a one pot operation is increasingly gaining the attention of the scientific community. However, literature known multicatalytic systems are very limited and challenging since ligand specificity and specific functional group activation by the different metal catalysts in a time resolved domino fashion is pivotal in such systems. This research serves to develop novel strategies in this budding field of multi-metallic domino reactions by utilizing rhodium/gold or rhodium/palladium to effect orthogonal activation of different functional groups. It is envisaged that the successful implementation of this single pot multi-metallic domino strategy would allow much more efficient access into biologically and industrially interesting scaffolds enantioselectively.