Characterization of the two receptor-kinases SOBIR1/EVR and BAK1 as co-receptors of the receptor-like protein RLP30 from Arabidopsis thaliana

植物已经适应了抵御微生物感染的防御机制。微生物配体与位于细胞表面的跨膜受体结合，触发细胞内的重新编程，最终限制病原体的生长。我们已经将拟南芥富含亮氨酸重复序列(LRR)受体样蛋白的一个成员RLP30与模式识别受体RLP30联系起来，作为模式识别受体来识别来自真菌病原菌核盘菌的一种新的激发子活性。此外，我们还发现两个富含亮氨酸重复序列的受体样激酶BAK1和SOBIR1/EVR可能是RLP30的辅助受体。这个项目的总体目标是破译RLP30介导的模式识别和随后通过RLP30-BAK1-SOBIR1/EVR受体机制进行的信号转导的分子机制。解开RLP30/BAK1/SOBIR1介导的模式感知的作用模式，将加深我们对SOBIR1/EVR作为LRR型受体样蛋白的新的辅助受体的机制的理解，并将拓宽我们对植物如何适应有害生物环境的认识。

Plants have adapted defence mechanisms to resist microbial infection. Binding of microbial ligands to transmembrane receptors that are located at the cell surface trigger intracellular re-programming eventually leading to restriction of pathogen growth. We have associated one member of the Arabidopsis leucine-rich repeat (LRR) receptor-like proteins, RLP30, with a specific function as pattern recognition receptor for a novel elicitor activity from the fungal pathogen Sclerotinia sclerotiorum. Moreover, we have identified the two leucine-rich repeat receptor-like kinases BAK1 and SOBIR1/EVR as putative co-receptors of RLP30. The general objectives of this project will be to decipher the molecular mechanisms underlying RLP30-mediated pattern recognition and the subsequent signal transduction via the RLP30-BAK1-SOBIR1/EVR receptor machinery. Unravelling the mode of action of RLP30/BAK1/SOBIR1-mediated pattern perception will deepen our mechanistic understanding on SOBIR1/EVR as novel co-receptor for LRR-type receptor-like proteins and will broaden our knowledge on how plants adapt to a detrimental biotic environment.