Cytokine-driven allergic inflammation: characterization of two isoform-specific modes of IL-3 receptor activation and investigation of new receptor-associated signalling partners.

细胞因子驱动的过敏性炎症：IL-3 受体激活的两种亚型特异性模式的表征以及新受体相关信号传导伴侣的研究。

• 批准号: nhmrc : 1033368
• 负责人: A/Pr James Murphy
• 金额: $ 41.39万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytokine-driven-allergic-signalling-partners/110889
• 关键词: Cytokine; driven; allergic; inflammation; characterization

In asthma, the symptoms are caused by an allergic reaction in the lung orchestrated by immune cells which produce small proteins called cytokines thus stimulating inflammatory cell production. The cytokine IL-3 is critical for the production of basophils which have an important role in the inflammation. The project will investigate the molecular details of how the IL-3 binds to its receptor and stimulates basophil production and reveal new targets for controlling inflammation in asthma.

在哮喘中，症状是由肺中的过敏反应引起的，由免疫细胞协调，免疫细胞产生称为细胞因子的小蛋白质，从而刺激炎症细胞产生。细胞因子IL-3对嗜碱性粒细胞的产生至关重要，嗜碱性粒细胞在炎症中起重要作用。该项目将研究IL-3如何与其受体结合并刺激嗜碱性粒细胞产生的分子细节，并揭示控制哮喘炎症的新靶点。