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Cytokine-driven allergic inflammation: characterization of two isoform-specific modes of IL-3 receptor activation and investigation of new receptor-associated signalling partners.

Cytokine-driven allergic inflammation: characterization of two isoform-specific modes of IL-3 receptor activation and investigation of new receptor-associated signalling partners.
细胞因子驱动的过敏性炎症：IL-3 受体激活的两种亚型特异性模式的表征以及新受体相关信号传导伴侣的研究。
批准号：
nhmrc : 1033368
负责人：
A/Pr James Murphy
金额：
$41.39万
依托单位：
Australian National University
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2012
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2012-01-01 至 2015-12-31
来源：
https://researchdata.edu.au/cytokine-driven-allergic-signalling-partners/110889
关键词：
Cytokinedrivenallergicinflammationcharacterization

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中文摘要
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英文摘要
In asthma, the symptoms are caused by an allergic reaction in the lung orchestrated by immune cells which produce small proteins called cytokines thus stimulating inflammatory cell production. The cytokine IL-3 is critical for the production of basophils which have an important role in the inflammation. The project will investigate the molecular details of how the IL-3 binds to its receptor and stimulates basophil production and reveal new targets for controlling inflammation in asthma.
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Unconventional mechanisms for activating the NLRP3 inflammasome
  • 批准号：
    nhmrc : GNT1145788
  • 项目类别：
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  • 资助金额：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
Unconventional mechanisms for activating the NLRP3 inflammasome
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
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