Pathogen recognition by taste and odorant receptors and coupling to BALT formation and epithelial remodeling (A06)

特殊的化学感觉上皮细胞利用典型的味觉转导级联来识别粘膜表面的细菌产物，并通过旁分泌胆碱能信号迅速激活粘液纤毛清除。现在，我们将检验我们的主要假设，即化学感觉细胞(刷状细胞和神经内分泌细胞)协调(1)BALT(三级淋巴滤泡)的形成和(2)感染诱导的上皮重塑，两者都通过(A)上皮旁分泌信号和(B)改变固有淋巴样细胞(ILC)功能，从而保护或限制肺部感染，利用新发现的小鼠病原体假性鼻炎杆菌作为模式生物，以及人类病原体肺炎克雷伯菌。

Specialized chemosensory epithelial cells utilize the canonical taste transduction cascade to recognize bacterial products at the mucosal surface and acutely activate mucociliary clearance through paracrine cholinergic signaling. We will now test our major hypothesis that chemosensory cells (brush and neuroendocrine cells) orchestrate (1) BALT (tertiary lymphoid follicles) formation and (2) infection-induced epithelial remodeling, both via (a) intraepithelial paracrine signaling and (b) modifying innate lymphoid cell (ILC) functions, thereby protecting from or limiting pulmonary infection, utilizing the newly identified murine pathogen B. pseudohinzii as a model organism, and the human pathogen Klebsiella pneumoniae.