Quantification of magnetic nanocomposites through cross-calibration of MR and X-ray imaging.

这个特殊研究项目的目的是利用MRI和XCT技术分析和量化纳米颗粒在幻影和生物组织中的分布，从而确定最准确和一致的纳米颗粒量化方法。在磁性药物靶向（MDT）过程中，需要纳米颗粒定量分析药物分布或为手术提供增强对比。这对患者是有益的，因为诊断可以更准确和及时，减少潜在的错误和代价高昂的低效率。结合使用XµCT和MRI可以增加获得的信息，增强定量成像的有效影响。我们的方法是对XµCT和MRI进行交叉校准。为此，将开发、应用和测试一种适用于MRI和XCT的幻影系统。结果将是纳米颗粒含量及其生物分布的三维定量与标准成像技术。量化的结果可以应用于各种生物医学应用，其中磁性纳米颗粒起着关键作用。

The aim of this particular research project is to analyse and quantify nanoparticle distributions within a phantom and biological tissue using both MRI and XCT technologies, and thus determine the most accurate and consistent methodology for nanoparticle quantification. Nanoparticle quantification would be required to analyse drug distribution during magnetic drug targeting (MDT) or for providing enhanced contrast for surgery. This is beneficial to the patient as diagnosis can be more accurate and timely, reducing the potential for mistakes and costly inefficiencies. Use of both, XµCT and MRI, in combination could increase the information attained and enhance the effective impact of the quantitative imaging. Our approach to this is to perform a cross-calibration of XµCT and MRI. For this a phantom system suitable for MRI and XCT will be developed, applied and tested. The result will be a 3-dimensional quantification of the nanoparticle content and their biodistribution with a standard imaging technique. The outcome of the quantification can then be applied to various biomedical applications where magnetic nanoparticles play a key role.