Structural and functional diversity of the axon initial segment of principal neurons in hippocampal ensembles. (A03)

携带轴突的树突（AcDs）是海马锥体细胞兴奋性突触输入的一种特殊通道。我们可以证明，ACD和nonACD细胞被不同地招募到功能集合中，并假设特权输入通道可以通过不同的功能状态（即网络振荡）进行动态调节。在这种情况下，我们要测试如何在皮质发育过程中，他们是如何受特定的兴奋性和抑制性输入，以及他们是否保持结构和功能的塑料在整个生命。因此，我们预计有助于重要的问题，细胞机制如何确定状态和经验依赖的合奏形成。

Axon-carrying dendrites (AcDs) constitute a privileged channel for excitatory synaptic input in a subset of hippocampal pyramidal cells. We could show that AcD and nonAcD cells are differently recruited into functional ensembles and hypothesize that the privileged input channel can additionally be dynamically regulated by different functional states (i.e. network oscillations). In this context we want to test how AcDs are developed during corticogenesis, how they are innervated by specific excitatory and inhibitory inputs, and whether they remain structurally and functionally plastic throughout life. Thus, we anticipate contributing to important questions on how cellular mechanisms determine state- and experience-dependent formation of ensembles.