Size matters, but at what cost? Role of male sex hormones in the placenta

该项目旨在了解胎盘中男性性激素调节的分子途径，这些途径可能有助于特定性别胎儿的生长和存活结果，以应对氧气和/或葡萄糖减少。通过这个项目，我们希望通过跨学科的方法，产生关于驱动特定性别胎盘分子功能的机制的新知识。在未来的研究中，对胎盘分子功能和胎儿生长的性别特异性调控的这一高级理解的应用可能会成为改善家畜、家养宠物和人类等胎盘哺乳动物的胎儿生长结果的目标。

This project aims to understand molecular pathways regulated by male sex hormones in the placenta that may contribute to sex-specific fetal growth and survival outcomes in response to reduced oxygen and/or glucose. Through this project, we expect to generate new knowledge of the mechanisms that drive sex-specific placental molecular function using interdisciplinary approaches. The application of this advanced understanding of the sex-specific regulation of placental molecular function and fetal growth may be targeted in future studies to improve fetal growth outcomes in placental mammals such as livestock, domestic pets, and humans.