Deciphering genome function in animal development

胚胎的正常发育依赖于复杂和微调的基因调控机制。在这个团契中，我将使用尖端的新技术来发现我们30,000个基因中哪些对胚胎发育是重要的，揭示这些基因的作用，并确定可能出错导致出生缺陷的控制机制。我们的研究将提出诊断和处理这些疾病的新方法，并将适用于干细胞技术、组织再生、癌症生物学、保护、虫害管理和家畜饲养，从而为澳大利亚带来显著的经济和社会效益。

The normal development of an embryo depends on complex and finely tuned gene regulatory mechanisms. In this Fellowship, I will use sophisticated new technologies to discover which of our 30,000 genes is important for embryonic development, reveal the roles of these genes, and identify the control mechanisms that can go awry to cause birth defects. Our research will suggest new ways to diagnose and deal with these conditions, and will be applicable to stem cell technologies, tissue regeneration, cancer biology, conservation, pest management and livestock breeding, thus delivering significant economic and social benefits to Australia.