The More the Merrier? Investigating copy number variation in Brassicas

该项目旨在加深对基因拷贝数变异如何影响疾病易感性的理解，以帮助设计新的植物保护策略。基因拷贝数变异(CNV)是指在一个个体或品系的基因组中相对于另一个个体或品系复制或丢失的DNA片段。CNV已被证明对人类的表型差异有很大贡献，包括疾病易感性，这似乎也适用于植物。该项目旨在应用十字花科植物的基因组序列从重新测序数据中检测CNV。了解这种变异如何影响个体或品系的疾病易感性，特别是对毁灭性的真菌病原体黑腿的敏感性，可以改善植物保护策略和作物产量。

This project intends to develop an understanding of how gene copy number variation affects disease susceptibility to help in the design of novel plant protection strategies. Gene copy number variants (CNVs) are segments of DNA that have been duplicated or lost in the genome of one individual or line with respect to another. CNVs have been shown to contribute significantly to phenotypic differences in humans, including disease susceptibility, and the same seems to apply in plants. This project aims to apply the genome sequences for Brassica species to detect CNVs from re-sequencing data. Knowing how this variation affects an individual or line’s disease susceptibility, especially to the devastating fungal pathogen blackleg, could improve plant protection strategies and crop production.