Functional regulation of the mitochondrial presequence translocation complex (P12)

真核细胞中超过一半的蛋白质必须穿过至少一个膜才能到达它们的指定位置。在几乎所有的细胞膜中，蛋白质易位机制已经被确定，它们要么运输蛋白质穿过膜，要么促进它们插入特定的膜。在许多这些转运机制的核心，蛋白质传导孔已被发现介导进口，出口和膜插入。该项目的重点是TIM23和Hrd1复合物中两个蛋白质传导孔的分子表征，涵盖了所有三种提到的蛋白质转运途径。

Over half of the proteins of a eukaryotic cell have to cross at least one membrane to reach their designated localization. In virtually all cellular membranes protein translocation machineries have been identified that either transport proteins across a membrane or facilitate their insertion into a particular membrane. At the heart of many of these translocation machineries protein conducting pores have been found that mediate import, export and membrane insertion. This project focuses on the molecular characterization of two protein conducting pores within the TIM23 and the Hrd1 complexes, that cover all three mentioned protein transport pathways.