哺乳類のDNA複製タイミング制御におけるゲノムとエピゲノムの機能的リンク

真核生物基因组被组织成富含基因的异染色质结构域，而异染色质结构域缺乏基因，转录不活跃。Eu或异染色质也类似于A或B隔室，根据Hi-C(一种染色质构象捕获方法)的特征向量的PC1(主成分1)值计算。在S期，A室早复制，B室晚复制。然而，尚不清楚A/B划分和早/晚复制时间是否在机械上联系在一起。

The eukaryotic genome is organized into eu- or hetero-chromatin domains, the former is gene-rich and transcriptionally active, while the latter is gene-poor and transcriptionally inactive. Eu- or hetero-chromatin are also analogous to A or B compartments, calculated from the PC1 (primary component 1) value of the eigenvector of the Hi-C (a method for chromatin conformation capture) matrix. During S phase, A compartments replicate early while B compartments replicate late. It is, however, not understood if A/B compartmentalization and early/late replication timing is mechanistically linked.