The influence of gut microbiota composition and diversity on the resorption and de novo synthesis of fatty acids in the small intestine

哺乳动物肠道微生物区系是一个复杂的生态系统，其组成和多样性取决于饮食、环境、健康和疾病等多种因素。我们的初步数据有力地表明，肠道微生物区系影响膳食脂肪的吸收、肠道脂肪酸的运输、从头合成和分泌进入循环。肠道脂肪代谢的失调可能与代谢超负荷有关。此外，肠道FA的合成可能参与了肠道屏障功能的形成和相关的炎症病理。肠道微生物区系可能是调节膳食脂肪吸收和肠道脂肪合成的有吸引力的靶标。因此，这个项目的主要目标是调查肠道微生物区系的组成和多样性是否以及如何影响脂肪酸的吸收、肠道脂肪的合成和储存。这包括它对肠道屏障的脂质成分的影响，以及微生物群衍生的短链脂肪酸的作用。

The mammalian gut microbiota is a complex ecosystem, its composition and diversity depends on various factors including diet, environment, health and disease. Our preliminary data strongly indicate that gut microbiota influence absorption of dietary lipids, intestinal fatty acid trafficking, de novo synthesis and secretion into the circulation. A dysregulation of the intestinal lipid metabolism may be associated with metabolic overload. Moreover, intestinal FA synthesis may be involved in the formation of the intestinal barrier function and associated inflammatory pathologies. Gut microbiota might represent attractive targets for modulating dietary lipid resorption and intestinal lipid synthesis. Therefore, the primary objectives of this project are to investigate if and how gut microbiota composition and diversity affects the resorption of fatty acids, intestinal lipid synthesis and storage. This includes its effects on lipid composition of the intestinal barrier as well as the role of microbiota derived short chain fatty acids.