Nanoagents for controlled manipulation of cell-ECM interaction (B11)

集体细胞侵袭和细胞迁移由细胞-ECM相互作用决定。为了研究这些过程，我们将使用表面声波来操纵矩阵，这是我们在上一个资助期开发的工具。此外，我们将使用上一个资助期的光遗传学构建来控制细胞中的机械传感。我们将使用和改进这些工具来研究从球体到周围矩阵的集体入侵。

Collective cell invasion and cell migration are determined by cell-ECM interactions. To study these processes we will thus apply tools to manipulate the matrix using surface acoustic waves, which we have developed in the previous funding period. Furthermore, we will use an optogenetic construct from the last funding period to control mechanosensing in the cell. We will employ and refine those tools to investigate collective invasion from a spheroid into the surrounding matrix.