SPP 1316: Host-adapted Metabolism of Bacterial Pathogens

是什么使细菌与宿主生物一起繁殖并引起疾病？要回答这个问题，仅仅了解特定毒力决定因素（如毒素或侵入物）的功能是不够的。传统上，与宿主防御的相互作用被定义为微生物致病性的基础，导致防御性和进攻性毒力决定因素的特征。最近，很明显，宿主和病原体的共同进化也导致了病原体代谢的适应。例如“健康因素”，如铁摄取系统或代谢途径的减少或延长。最近发展的高度敏感的生物分析技术现在可以深入研究病原体代谢对宿主生物的适应性。在这个优先规划的框架内，研究人员将研究细菌病原体如何在宿主生物定植期间适应它们的代谢，致病菌和宿主生物的代谢如何相互联系，以及哪些控制机制是活跃的。这一优先方案的项目旨在查明在感染期间对细菌很重要的代谢途径，并确定代谢通量。宿主生物的代谢反应和代谢适应的遗传机制将被揭示。该方案的具体目标是：

What enables bacteria to proliferate with their host organisms and to cause disease? To answer this question, it is not sufficient to understand the function of specific virulence determinants such as toxins or invasins. Traditionally, the interaction with the host defense has been defined as the basis microbial pathogenicity, leading to the characterisation of defensive and offensive virulence determinants. More recently, it became obvious that the co-evolution of host and pathogen also resulted in an adaptation of the metabolism of the pathogen. Examples are "fitness factors" such as iron uptake systems or the reduction or extension of metabolic pathways. Recently developed highly sensitive bioanalytical techniques now allow the in-depth study of the adaptation of the pathogen's metabolism to the host organism. In the framework of this Priority Pogramme researchers will investigate how bacterial pathogens adapt their metabolism during colonisation of host organisms, how the metabolism of pathogenic bacteria and host organism is interconnected and which mechanisms of control are active. Projects in this Priority Pogramme aim to identify metabolic pathways that are important for the bacteria during infection and to determine the metabolic fluxes. The metabolic reactions of the host organisms and the genetic mechanisms of metabolic adaptation will be unraveled. Specific aims of the programme are: