From Pavlov to Pain: Extinction Learning in Visceral pain (A10)

来自肠道的内感受性信号，特别是内脏疼痛，可能以某种方式塑造学习和记忆过程，尽管它们具有深远的临床意义，但仍未完全理解。实施一个包括伤害性内脏和非伤害性听觉威胁的条件反射范式，我们将进行一项双盲、随机、安慰剂对照的行为研究，以测试应激激素皮质醇对消退效果的模式特异性影响。在一种新的具有内感受性CS的情境依赖的内感受性条件反射范式中，我们将进一步描述情境内感受性威胁和安全学习、消失和恐惧的复苏的神经基础，作为肠-脑轴疾病中涉及的内感受性高警觉性的假设机制。

Interoceptive signals arising from the gut, especially visceral pain, may shape learning and memory processes in ways that, despite their profound clinical relevance, remain incompletely understood. Implementing a conditioning paradigm involving nociceptive visceral and non-nociceptive auditory threats, we will conduct a double-blind, randomized, placebo-controlled behavioral study to test modality-specific effects of the stress hormone cortisol on extinction efficacy. In a novel context-dependent interoceptive conditioning paradigm with interoceptive CS, we will further delineate neural underpinnings of contextual interoceptive threat and safety learning, extinction, and the resurgence of fear as putative mechanisms involved in interoceptive hypervigilance in disorders of the gut-brain axis.