Stereocontrol in the intramolecular addition of chromones to alpha-ketoester and alpha,beta-diketoester: syntheses of preussochromones and diversonolic ester

该项目的目标是研究色酮与α-酮酯和α，β-二酮酯的立体选择性分子内加成反应。对于计划中的5元环和6元环的环化反应，重点是通过现有的立体中心来控制底物的可能性，以及通过手性、螯合路易斯酸来控制催化剂的可能性。建议研究的参照点是色酮前的天然产物色酮A、D、E、F和多元醇酯α和β。

Goal of the project is to investigate the stereoselective, intramolecular addition of chromones to alpha-ketoester and alpha,beta-diketoester. For the planned cyclizations to 5- and 6-membered rings the focus is on possibilities of substrate control by existing stereo centers and of catalyst control by chiral, chelating Lewis acids. Reference points for the proposed studies are the chromone natural products preussochromone A, D, E, F and the diversonolic ester alpha and beta.