Titanium/polymer sheets designed for biomedical application; Feasibility study

IMET， TU Clausthal和IPCMS， Uni Strasbourg的研究小组已经合作了十年，为汽车应用开发和表征金属/聚合物组合的夹层材料。几年前，它将其活动扩展到生物医学应用领域，并提出了有关生物相容性材料组合的新挑战。由于环氧树脂在汽车上的应用并不重要，在生物医学上也不适用，因此有必要为这些金属和聚合物材料的组合开发新的良好和安全的粘合方法。总体项目的目标是设计用于生物医学应用的新型钛(Ti)/聚合物(P)/钛混合材料片，控制其界面，机械性能和成型行为。这些可用于颅骨成形术和下颌骨手术的系统的优点将是一个轻量级的多层系统，具有分级强度条件，相对于单独的钛而言，具有改进的热学和声学性能，并且具有可以设计成接近骨骼的机械性能。这些系统的详细设计、工艺开发、性能分析及其成形限制预计将在法国和德国合作伙伴之间协同进行，主要目标是：1)使用新开发的化学工艺来设计P/Ti界面，不含环氧树脂，目前用于汽车应用的夹芯板（SMs）中的粘合剂。2)制造Ti/P/Ti或Ti/P复合材料用于颅骨成形术和下颌骨手术，使其具有接近骨骼行为的定制力学性能。到目前为止，IPCMS研究的新接枝方法可以成功地引入到10 × 10 mm²的Ti表面。聚合引发剂可以通过磷酸盐锚接枝到改性的Ti（1级）片表面。通过控制自由基聚合过程，可以从引发剂生长出厚度约为1微米的聚甲基丙烯酸甲酯（PMMA）线性聚合物链。这个短期项目（9个月）的目的是研究使用这种嫁接方法生产三明治片的可行性（针对A6甚至A5尺寸）。预计研究结果将用于下一个DFG-ANR计划中的一个新的、加强的和最终的双边项目。可预见的步骤如下。以均匀的方式制备金属板表面，没有缺陷或金属涂层的强烈（减弱？）差异。寻找合适的工艺条件，将单层与a3组合成夹层纸。合适的，可复制的键。

The research group of IMET, TU Clausthal, and IPCMS, Uni Strasbourg, is working together since a decade of years developing and characterizing sandwich sheet materials of metal/polymer combinations for automotive applications. It extended its activities into the field of biomedical use with new challenges concerning the combination of biocompatible materials some years ago. As the use of epoxy resins, uncritical for the automotive, is not applicable for biomedical use, new ways for a good and safe bonding are necessary to be developed for these combinations of metal and polymer materials. The goal of the general project is the design of new titanium(Ti)/polymer(P)/Ti hybrid sheets to be used for biomedical applications, the control of their interface, their mechanical properties and shaping behavior. The advantages of these systems usable for cranioplasty and mandible surgery will be a lightweight multilayer system with graded strength conditions and improved thermal and acoustic properties with respect to titanium alone, and with mechanical properties that can be designed close to the bones ones. The elaboration of these systems, the process development, the analysis of the properties and their forming limits is foreseen to be performed in synergy between the French and German partners with the main objectives:1) Use a new developed chemical process to design P/Ti interfaces free of epoxy resins currently used as adhesive agents in sandwich sheets (SMs) for automotive applications. 2) Fabricating Ti/P/Ti or Ti/P SMs for cranioplasty and mandible surgery with tailored mechanical properties close to the bones behaviour.Up to now, the new grafting from method, investigated by IPCMS, could successfully be introduced for a Ti surface 10 x 10 mm². A polymerization initiator could be grafted on a modified Ti (Grade 1) sheet surface via a phosphonate anchor. Linear polymer chains of polymethylmethacrylate (PMMA) could be grown from the initiator using a controlled radical polymerization process up to a thickness of approximately one micron. The aim of this short time project (9 months) is to investigate the feasibility of using this grafting from method to produce sandwich sheets (aiming at size A6 or even A5). The results are foreseen to be used for a new, strengthened and final bilateral project within the next DFG-ANR program.The steps foreseen are to1. prepare the metal sheet surface in a homogeneous way without defects or strongly (weakening?) differences in the layer coated on the metal,2. find suitable process conditions for combining the single layers to a sandwich sheet with a3. suitable, reproducible bond.