Enantioselective Synthesis and Functionalization of Heptacyclo[6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane and Related Cage Compounds

在本研究项目中，对七环十四烷（HCTD）的高效合成和区域选择性和对映选择性（多）功能化提出了不同的方法。鉴于HCTD与金刚烷衍生笼体（特别是金刚烷）之间的结构关系，以及这些化合物在药物化学或材料科学等多种领域的应用数量；设想功能化的HTDC也可能是修改药物或设计机械化学装置的有趣的构建块。如果成功，这个研究项目将打开一个快速进入这些结构。最后，我们计划对其实际效用进行初步测试。

Along this research project different approaches dealing with the efficient synthesis and the regio- and enantioselective (poly)fuctionalization of heptacyclo [6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane (HCTD) are proposed. Given the structural relationship between HCTD and adamantane derived cages, in particular diamantane, and the number of applications that these compounds have found in areas as diverse as medicinal chemistry or material science; it is envisaged that functionalized HTDC might also be interesting building blocks for the modification of drugs or the design of mechanochemical devices. In case of success, this research project will open an expeditious entry to these structures. Finally, we plan to preliminary test their practical utility.