生体活性人工血管の開発と血管組織修復のための免疫調節の役割の解明

本研究的目的是培育具有指导意义的生物材料，以促进原位组织修复。可溶性和拴系的生物信号以及细胞外基质（ECM）模拟支架具有很大的前景。生长因子（growth factors，GF）、细胞因子和趋化因子在组织修复中起着关键作用，但由于其半衰期短、稳定性差，在体内外均易被降解。短氨基酸序列可以完全概括全长蛋白质的生物活性，同时确保易于制造和良好的稳定性，这提供了一种替代范例。因此，本财政年度研究的首要目标是制造ECM模拟支架，并使用GF和其他生物活性因子对其进行修饰，以实现功能性组织修复。

The objective of this research is to foster instructive biomaterials to promote in situ tissue repair. Soluble and tethered biological cues as well as extracellular matrix (ECM)-mimicking scaffolds hold great promise. Growth factors (GFs) as well as cytokines and chemokines play a pivotal role for tissue repair, however, they can be easily degraded in vitro and in vivo owing to their short half-life and poor stability. Short amino-acid sequences, which can fully recapitulate the bioactivity of full-length proteins while ensuring an easy manufacturing and good stability offer an alternative paradigm. Therefore, the overarching goal of research in this fiscal year was to fabricate ECM-mimicking scaffolds and to modify them with GFs and other bioactive cues for a functional tissue repair.