Development ofthe safely sterilization agent for prevention of secondary prion infection through medical instruments

众所周知，异常朊病毒蛋白对标准灭菌或化学清洗具有高度抗性，并且需要高温高压或强化学处理来灭菌其感染性，然而，这些严格的处理不适用于某些精密医疗器械，例如内窥镜。本研究探讨锰过氧化物酶对朊病毒感染性的降解和灭菌能力，并尝试开发一种新型的安全的精密医疗器械灭菌剂。

It has been well-known that abnormal prion protein is highly resistant against standard sterilization or chemical cleaning, and that high temperature-pressure or strong chemical treatment are required to sterilize its infectivity, however, these severe treatments are not applicable to some precision medical instrument, such as endoscopes. In this study, we investigated a capability of the enzyme, manganese peroxidase, to degrade and sterilize prion infectivity and tried to develop a new safely sterilization agent for precision medical instruments.