Precision macromolecules for the sequence-controlled presentation of supramolecular ligands (A11+)

我们将应用序列控制的寡（酰胺基胺）作为一个新的平台，用于与生物配体和传感器分子（A10）组合的非天然超分子结合基序（A1，A2，A3）的多价呈现。将分析所得大分子配体对不同蛋白质的调节，例如p97（B2）、14-3-3蛋白（B4）、存活素和Taspase 1（B5）的N-D1界面、有丝分裂调节剂（B6）和Ndc 80-微管相互作用（B7）。

We will apply sequence-controlled oligo(amidoamines) as a new platform for the multivalent presentation of non-natural supramolecular binding motifs (A1, A2, A3) in combination with biological ligands and sensor molecules (A10). The resulting macromolecular ligands will be analyzed for their modulation of different proteins such as the N-D1 interface of p97 (B2), 14-3-3 protein (B4), Survivin and Taspase1 (B5), mitotic regulators (B6) and Ndc80-microtubule interactions (B7).